Sep 1, 1981

The influence of carbamazepine on thyroid hormones and thyroxine binding globulin in hypothyroid patients substituted with thyroxine

Clinical Endocrinology
S AanderudRoald E Strandjord

Abstract

Carbamazepine (CBZ) decreases the serum concentration of thyroid hormones. It is proposed that CBZ increases the extra-thyroidal metabolism of thyroid hormones. In order to test this hypothesis CBZ was given to nine hypothyroid patients substituted with thyroxine (T4). A significant decrease in serum concentrations of T4, calculated free T4 (FT4), triiodothyronine (T3), and calculated free T3(FT3) was found after 3 weeks of CBZ medication. The serum concentrations of TSH and the T4:T3 ratios were unaltered, while the serum concentrations of T4-binding globulin (TBG) increased markedly in eight of the nine patients. These findings support the hypothesis of a CBZ induced increase in the extra-thyroidal metabolism of thyroid hormones.

Mentioned in this Paper

Metabolic Process, Cellular
Novothyral
Thyroxine-Binding Globulin
T4 Free Measurement
Carbamazepine
Free Triiodothyronine Assay
Thyroxine Measurement
Hypothyroidism
Thyrotropin
Metabolic Pathway

About this Paper

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