PMID: 9161906May 1, 1997Paper

The influence of cardiopulmonary bypass on cytokines and cell-cell communication

Journal of Cardiothoracic and Vascular Anesthesia
G E HillD F Landers

Abstract

Cardiopulmonary bypass (CPB) is characterized by systemic endotoxemia immediately after its onset as well as the systemic release of proinflammatory cytokines, including tumor necrosis factor-alpha and the interleukins 1 and 6. Recent studies document that increased morbidity and mortality rates correlate with elevated systemic concentrations of these proinflammatory cytokines during adult and neonatal sepsis, following thoracoabdominal aortic aneurysm repair, as well as following CPB. These proinflammatory cytokines induce increased neutrophil and endothelial surface adhesive molecule expression, thereby promoting enhanced neutrophil-endothelial adherence. Increased neutrophil-endothelial adherence and subsequent neutrophil organ binding are thought to be a "final common pathway" of organ injury during clinical inflammatory conditions. Proinflammatory cytokines also increase cellular expression of inducible nitric oxide synthase, thus increasing cellular production of nitric oxide, a known inflammatory mediator. This review discusses recent evidence of the adverse effects of proinflammatory cytokine release during CPB and therapeutic modalities that can reduce the systemic concentrations of these mediators of inflammation.

References

Apr 7, 1977·The New England Journal of Medicine·P R CraddockH S Jacob
Jan 14, 1992·European Journal of Pharmacology·M G BelvisiP J Barnes
Nov 1, 1992·The Journal of Clinical Investigation·B J HughesC W Smith
Jun 1, 1992·The British Journal of Surgery·R A LordJ L Francis
Oct 1, 1992·The Annals of Thoracic Surgery·N J JansenC R Wildevuur
Oct 20, 1992·European Journal of Pharmacology·H P KuoP J Barnes
Sep 1, 1992·Critical Care Medicine·P D MacnaughtonT W Evans
Jan 1, 1990·Critical Reviews in Microbiology·R Burrell
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M W RadomskiS Moncada
Jan 1, 1991·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·N J JansenC R Wildevuur
Sep 1, 1991·Anesthesiology·C S RinderR Hillman
Sep 16, 1991·Biochemical and Biophysical Research Communications·N TodorokiT Osawa
Dec 1, 1991·European Journal of Clinical Investigation·A Billiau, F Vandekerckhove
Aug 2, 1990·Nature·T A Springer
Apr 1, 1990·Immunological Reviews·T M Carlos, J M Harlan
Sep 21, 1990·Science·R R SchumannR J Ulevitch
Oct 1, 1989·Journal of Cardiothoracic Anesthesia·L W AndersenJ P Rasmussen
Jan 1, 1989·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·O RoeiseA O Aasen
Nov 13, 1987·Biochemical and Biophysical Research Communications·M W RadomskiS Moncada
Aug 1, 1988·Journal of Applied Physiology·J TumenK L Brigham
Sep 1, 1986·Resuscitation·G Schlag, H Redl
Jun 1, 1988·The American Review of Respiratory Disease·G FolkertsF P Nijkamp
Jun 1, 1986·The Journal of Experimental Medicine·C A DinarelloJ V O'Connor
Feb 12, 1987·The New England Journal of Medicine·B Beutler, A Cerami
Sep 1, 1986·The Journal of Clinical Investigation·B N CronsteinR Hirschhorn
Nov 1, 1986·The Journal of Clinical Investigation·R H SimonR F Todd
Jan 1, 1985·Annual Review of Medicine·A Janoff
Mar 1, 1974·The British Journal of Surgery·J E TrapnellE H Duncan
Dec 1, 1995·Anesthesia and Analgesia·J BoldtG Hempelmann

❮ Previous
Next ❯

Citations

Jul 21, 1998·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·G E HillC W Whitten
Feb 10, 1998·The Annals of Thoracic Surgery·G E HillR Pohorecki
Jun 13, 2002·Anaesthesia·R M HeamesD A Hett
Aug 2, 2007·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Huimin HuangHaibo Zhang
Jan 13, 2010·Journal of Cardiothoracic Surgery·Efstratios E ApostolakisGeorgios S Papadopoulos
Sep 1, 2012·Journal of Cardiothoracic Surgery·Algimantas BudrikisSarunas Kinduris
Oct 21, 2009·Critical Care : the Official Journal of the Critical Care Forum·Catherine MorganPeter Gill
Jun 23, 2006·Anesthesia and Analgesia·Andrew D MaslowArun K Singh
May 29, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Hirotsugu KurobeTetsuya Kitagawa
Feb 21, 2002·Journal of Cardiothoracic and Vascular Anesthesia·Richard I Hall
Aug 25, 2015·Journal of Cardiothoracic and Vascular Anesthesia·Mercedes Garcia-AlvarezRinaldo Bellomo
Jul 2, 2011·The Annals of Thoracic Surgery·György LangWalter Klepetko
Jul 31, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Francesco OnoratiAttilio Renzulli
Jan 6, 2000·Journal of Cardiothoracic and Vascular Anesthesia·A MaslowR G Johnson
Jun 3, 2004·The Annals of Thoracic Surgery·Fabien DoguetJean Paul Bessou
Jul 26, 2006·The Annals of Thoracic Surgery·Thomas ModineTerence Gourlay
Oct 18, 2003·Anesthesiology Clinics of North America·Tatjana Pintar, Charles D Collard
Mar 21, 2003·The Annals of Thoracic Surgery·Ivar RisnesJan L Svennevig
Feb 9, 2002·The Annals of Thoracic Surgery·David P NelsonEllis J Neufeld
Jun 25, 2009·Journal of Cardiac Surgery·Efstratios ApostolakisDimitris Dougenis
Jun 26, 2015·Journal of Cardiothoracic Surgery·Rawa ArifMatthias Karck
Jun 25, 2014·Postgraduate Medical Journal·Gang Wang, Changqing Gao
Oct 29, 2000·Journal of Cardiothoracic and Vascular Anesthesia·G KunstJ Motsch
Aug 15, 2006·Molecular Immunology·Bo NilssonJohn D Lambris
Feb 7, 2017·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Wei-Jian WangPeng-Bo Zhang
Aug 26, 1998·Journal of Cardiothoracic and Vascular Anesthesia·C Ramamoorthy, A M Lynn
Oct 17, 2008·Electrophoresis·Andrew WeeDavid Smith
Mar 1, 2006·Critical Care Medicine·Massimo ChelloElvio Covino

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Aortic Aneurysm

An aortic aneurysm is the weakening and bulging of the blood vessel wall in the aorta. This causes dilatation of the aorta, which is usually asymptomatic but carries the risk of rupture and hemorrhage. Find the latest research on aortic aneurysms here.

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.