The influence of catecholamines and serotonin on histamine uptake and metabolism by guinea pig atrium

European Journal of Pharmacology
F MoroniP F Mannaioni


The influence of serotonin and catecholamines on the uptake and metabolism of 14C-histamine by isolated guinea pig atrium has been investigated. Epinephrine, norepinephrine and serotonin were found to reduce the histamine uptake and the formation of methylhistamine, in a dose-dependent fashion. The order of potency was epinephrine greater than norepinephrine greater than serotonin. Aliphatic diamines, such as spermine, do not affect the accumulation and metabolism of histamine. It is suggested that serotonin and catecholamines, may enhance histamine responses by decreasing the uptake and metabolism of this amine.


Feb 1, 1976·European Journal of Pharmacology·W C De Mello
Feb 1, 1976·European Journal of Pharmacology·I JosephsonN Sperelakis
Nov 1, 1973·British Journal of Pharmacology·P F Mannaioni, F Moroni
May 1, 1970·British Journal of Pharmacology·M A Reilly, R W Schayer
Feb 1, 1972·Biochemical Pharmacology·J Jester, W D Horst
Nov 1, 1971·European Journal of Pharmacology·J C SchwartzM Verdiere-Sahuque
Jul 1, 1967·Acta Physiologica Scandinavica·O Eränkö, S E Jansson
Jul 1, 1965·Acta Physiologica Scandinavica·O Eränkö, L Kauko
Oct 1, 1958·Biochimica Et Biophysica Acta·Z ROTHSCHILD, R W SCHAYER
Aug 1, 1960·The American Journal of Physiology·T SZILAGYIB CSABA
Jan 1, 1962·The American Journal of Physiology·J A COPPOLA, J R DI PALMA
Dec 1, 1963·British Journal of Pharmacology and Chemotherapy·L L IVERSEN
Oct 1, 1964·British Journal of Pharmacology and Chemotherapy·M DAY, A STOCKBRIDGE
May 4, 1936·The Journal of Physiology·G V AnrepM Talaat

❮ Previous
Next ❯


Apr 1, 1982·Agents and Actions·F Erjavec
Mar 1, 1987·Circulation Research·J A Bevan, J E Brayden

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.