The influence of CD4+ CD25+ Foxp3+ regulatory T cells on the immune response to rotavirus infection.

Vaccine
Bumseok KimHarry B Greenberg

Abstract

Rotavirus (RV) infection of the intestine is the major cause of severe dehydrating diarrhea in infants around the world. Although protective immunity against RV, especially acquired B and T-cell responses, has been extensively studied, our understanding of RV immunity remains incomplete. In addition, the interaction between various protective immune mechanisms in the gut and specific enteric immune suppressor systems that normally exert a regulatory function on mucosal immunity has not been extensively investigated. Among the candidate suppressor systems, we hypothesized that CD4+ CD25+ Foxp3+ regulatory T (Treg) cells may play a role in modulating RV immunity since such cells are naturally present in large numbers in the intestine and function nonspecifically. Here we demonstrate that neonatal murine RV (EC) infection induces an expansion of the Treg cell population and the magnitude of the T cell mediated immune response is modulated by Treg cells. Accordingly, when natural Treg cells in neonatal mice were depleted before virus infection, both CD4+ and CD8+ T-cell responses to RV, such as proliferation and IFN-gamma secretion, were enhanced in mesenteric lymph nodes (MLNs) and the spleen. Interestingly, increased proliferatio...Continue Reading

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Jul 23, 2009·Current Opinion in Infectious Diseases·Miguel L O'RyanGonzalo Osorio
Dec 2, 2015·Experimental and Therapeutic Medicine·Huaifu DongJiahua Pan
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Mar 2, 2021·Frontiers in Immunology·Terhi RuohtulaUNKNOWN DIABIMMUNE Study Group

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