PMID: 7032823Dec 1, 1981Paper

The influence of chronic high alcohol intake on blood pressure, plasma noradrenaline concentration and plasma renin concentration

Clinical Science
H IbsenJ Giese

Abstract

1. Sixteen 44-year-old males with chronic high alcohol intake were investigated. Seventeen 44-year-old males with low alcohol intake from the same population served as controls. 2. Plasma noradrenaline concentrations did not differ significantly between individuals with high and low alcohol intake, neither at rest nor after acute stimulation induced by ambulation for 15 min. However, 63% (10 out of 16) of the individuals with high intake showed resting values within the upper quartile range for individuals with low intake. 3. Plasma renin concentration was twice as high (P less than 0.01) in the group with high alcohol intake as in the group with low intake. 4. Systolic as well as diastolic blood pressure was significantly higher (P less than 0.01) in the group with high intake compared with the group with low intake. 5. Sympathetic nerve activity, as defined from measurements of plasma noradrenaline concentration, is not uniformly increased in individuals with chronic high alcohol intake. The mechanism behind the increased plasma renin level as well as the possible role of the renin--angiotensin system in alcohol-induced hypertension remain unsettled.

Citations

Jan 1, 1991·Clinical and Experimental Hypertension. Part A, Theory and Practice·J F Potter, D G Beevers
Mar 25, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Giorgio SoardoLeonardo A Sechi
Dec 24, 2003·Alcoholism, Clinical and Experimental Research·Ramón EstruchAlvaro Urbano-Márquez
Apr 1, 1997·Addiction Biology·I B PuddeyV Rakic
Aug 1, 2006·Journal of Hypertension·Giorgio SoardoLeonardo A Sechi
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