PMID: 20646612Jul 22, 2010Paper

The influence of chronic intermittent hypoxia on insulin function in OSAHS patients

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
Chun-ming XuJian-an Huang

Abstract

To discuss the influence of chronic intermittent hypoxia and secundum oxidative stress on insulin resistance and the function of Pancreatic beta cells in OSAHS patients. 15 patients with primary snoring, 31 patients with light to moderate OSAHS and 34 patients with severe OSAHS were investigated. General clinical data of every patient were collected, while nocturnal data were gained by using PSG with entire night monitor. 8-isoprostane and fasting insulin (FINS) were detected through ELISA; GSH-Px through Spectrophotometer. Insulin resistance was evaluated by measuring HOMA-IR and FINS, while the function of Pancreatic beta cells by HOMA-beta. The comparison among the three groups were used by the non-parametric Kruskal-Wallis H test, and Nemenyi test was used for pairwise comparison. The relativity between the variables were assessed by Spearman correlation test, and multiple linear regression was used to remove interference between variables. The enumeration data were compared with chi2 test. 1. Along with the aggravation of OSAHS, the three groups were statistically different from each other on 8-isoprostane, GSH-Px, fasting blood glucose (FBG), FINS, and HOMA-IR (P=0.0034, P<0.0001), but not on HOMA-beta (P>0.05). 2. ODI, C...Continue Reading

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