PMID: 2427681Jul 1, 1986

The influence of chronic or acute nicotine pretreatment on ethanol-induced gastric ulceration in the rat

The Journal of Pharmacy and Pharmacology
S H WongC H Cho


The effects in rats of chronic or acute nicotine pretreatment were studied on three gastric parameters: ethanol-induced ulceration, gastric wall mucus content and gastric acid secretion, under basal or histamine-stimulated conditions. Oral administration of ethanol (40%, 10 ml kg-1) depleted gastric wall mucus and produced ulceration in the gastric glandular mucosa. Ten-day nicotine pretreatment (15 or 25 micrograms ml-1 drinking water) worsened the adverse effects of ethanol on mucosal ulceration and mucus content, potentiated the gastric secretory action of histamine, but did not affect basal acid secretion. Single oral doses of nicotine (2 or 4 mg kg-1, given 1 h beforehand) prevented ulceration and mucus depletion in ethanol-treated animals; however, they did not influence either basal or histamine-stimulated gastric acid output. It is concluded that chronic nicotine administration aggravates ethanol ulceration, possibly by decreasing gastric wall mucus content and sensitizing the stomach to the acid secretory action of histamine. On the other hand, an acute oral dose of nicotine preserves the mucus content and prevents ethanol-induced ulcer formation.


Feb 1, 1976·The American Journal of Digestive Diseases·V P DinosoN S Murthy
Jan 1, 1976·European Journal of Pharmacology·C H ChoS Dai
Apr 2, 1985·European Journal of Pharmacology·C H ChoC W Ogle
Jan 29, 1986·European Journal of Pharmacology·M W KooC W Ogle
Sep 15, 1985·Experientia·C W OgleS H Wong
Feb 28, 1974·The New England Journal of Medicine·G D FriedmanC C Seltzer
Apr 1, 1970·European Journal of Pharmacology·K TakagiF Taga
Jul 1, 1968·British Journal of Pharmacology and Chemotherapy·S E Svensson, H Wetterqvist


Jan 1, 1991·Digestive Diseases and Sciences·K EndohF W Leung
Dec 1, 1992·Pharmacology, Biochemistry, and Behavior·B S QiuC W Ogle
May 15, 1996·Environmental Toxicology and Pharmacology·Donna WongC H Cho
Jan 5, 2002·European Journal of Pharmacology·Donna WongChi Hin Cho
Aug 23, 2002·European Journal of Pharmacology·Vivian Y ShinChi H Cho
Dec 16, 2005·Nature Clinical Practice. Gastroenterology & Hepatology·Gareth A O ThomasJohn R Ingram
Jan 1, 1997·Journal of Clinical Gastroenterology·G L Eastwood
Jan 1, 1994·Journal of Gastroenterology and Hepatology·C H ChoX L Tang
Aug 1, 1988·Biological Trace Element Research·F BarbarinoI Marinescu
Jul 1, 1988·The Journal of Pharmacy and Pharmacology·Y K PoonC W Ogle
Mar 1, 2009·Environmental Toxicology and Pharmacology·Mustafa DenizBerrak Ç Yeğen
Apr 27, 2004·Journal of Pharmacological Sciences·William K K Wu, Chi Hin Cho
Feb 24, 2001·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·J K KoC H Cho

Related Concepts

Gastric Acid
Structure of Pyloric Gland
Histamine Release
August Rats
Gastric Ulcer

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