The influence of citrate, maltolate and fluoride on the gastrointestinal absorption of aluminum at a drinking water-relevant concentration: A 26Al and 14C study

Journal of Inorganic Biochemistry
Yuzhao ZhouRobert A Yokel

Abstract

The objectives were to test the null hypotheses that (1) citrate, maltolate, and fluoride do not significantly influence oral Al bioavailability, C(max) or T(max) at an Al dose relevant to drinking water exposure; and (2) Al citrate and maltolate are absorbed intact from the gastrointestinal tract. Male Fisher rats were given 1ml of solution intra-gastrically containing 1 nCi (26)Al (65nmol total Al) as the Al(3+) ion, or as complexes with (14)C-citrate, (14)C-maltolate or fluoride, during concurrent (27)Al iv infusion. Blood was repeatedly collected for serum (26)Al, total Al and (14)C quantification. Absorption parameters were estimated using WinNonlin. Al bioavailability, C(max) and T(max) from the ion, citrate, maltolate, and fluoride were 0.29+/-0.11%, 0.61+/-0.31%, 0.50+/-0.25%, and 0.35+/-0.10%; 659+/-195, 1073+/-250, 881+/-356, and 880+/-295fg/ml; and 1.2+/-0.9, 1.0+/-1.1, 1.3+/-1.0, and 1.0+/-0.9h (X+/-SD) respectively. Serum (14)C was approximately 100 times higher than (26)Al. The results suggest a non-significant enhancement of oral Al bioavailability by citrate and maltolate, some Al complex dissociation in the GI tract, and less absorption of Al than citrate or maltolate. The presence of citrate, maltolate and flu...Continue Reading

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Citations

Feb 14, 2012·Biological Trace Element Research·Xin WuZe-Yuan Deng
Jul 7, 2009·Chemico-biological Interactions·Bitte Aspenström-FagerlundAnders W Glynn
Oct 14, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Robert A Yokel, Rebecca L Florence
Mar 14, 2016·Morphologie : Bulletin De L'Association Des Anatomistes·C VignalM Body-Malapel
Apr 26, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Robert A YokelRebecca L Florence
May 6, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Celeste Di PaoloMercedes Gómez
Jun 8, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Celeste Di PaoloMercedes Gómez
Sep 9, 2009·Journal of Inorganic Biochemistry·Ojeiru F EzomoShunsuke Meshitsuka
May 15, 2010·JPEN. Journal of Parenteral and Enteral Nutrition·Sandra R de OliveiraSimone Noremberg
Aug 21, 2013·Journal of Food Science·Carmen Cabrera-Vique, Marta Mesías
Sep 2, 2020·Critical Reviews in Toxicology·Robert A Yokel

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