The influence of clinical and genetic factors on left ventricular wall thickness in Ragdoll cats

Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology
K BorgeatDavid J Connolly

Abstract

To investigate the effect of various genetic and environmental modifiers on left ventricular (LV) wall thickness in a cohort of cats genotyped for the myosin binding protein C3 mutation (MYBPC3). Sixty-four Ragdoll cats. All cats were screened for HCM with echocardiography and genotyping for the HCM-associated MYBPC3:R820W mutation. Cats were also genotyped for previously identified variant polymorphisms of the angiotensin-converting enzyme (ACE) and cardiac beta-adrenergic receptor (ADRB1) genes. Plasma N-terminal pro-B-type natriuretic peptide and cardiac troponin I were also measured. Associations were evaluated between genotype (MYBPC3 negative/positive, and ACE and ADRB1 negative/heterozygous/homozygous), patient factors (body weight, age and sex) and echocardiographic measurements of LV wall thickness. Male cats had greater maximum wall thickness (LVmax; 5.8 mm, IQR 5.1-6.4 mm) than females (4.7 mm, IQR 4.4-5.3 mm, p = 0.002). Body weight positively correlated with LVmax (ρ = 0.604, p < 0.001). The MYBPC3:R820W-positive cats had a greater LVmax (5.44 mm, IQR 4.83-6.28 mm) than the negative cats (4.76 mm, IQR 4.36-5.32 mm, p = 0.001). Also, the ACE polymorphism genotype was associated with LVmax: the homozygous cats (5.37 ...Continue Reading

References

Sep 28, 2002·Human Molecular Genetics·Michael AradChristine E Seidman
Mar 20, 2003·European Heart Journal·L SwanW S Hillis
May 27, 2003·Journal of Feline Medicine and Surgery·L FerasinP R Wotton
Nov 3, 2004·Journal of the American College of Cardiology·Sara L Van DriestMichael J Ackerman
Nov 17, 2004·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Gysèle S BleuminkBruno H Ch Stricker
Nov 4, 2005·Circulation·Michael AradChristine E Seidman
Feb 25, 2006·Journal of Veterinary Internal Medicine·Jonathan A Abbott, Heidi N MacLean
Apr 3, 2008·Current Opinion in Cardiology·Ali J Marian
Jun 20, 2008·Acta Veterinaria Scandinavica·Suzanne GundlerJens Häggström
Jul 12, 2008·Journal of Molecular and Cellular Cardiology·Joanne M LindChristopher Semsarian
Jun 2, 2009·Journal of the American Veterinary Medical Association·Christopher F PaigeR Lee Pyle
Jul 11, 2009·Journal of the American College of Cardiology·Martin S MaronEvan Appelbaum
Oct 27, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Akira FunadaMasakazu Yamagishi
Nov 16, 2010·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·Tobias WagnerDavid Brodbelt
Mar 4, 2011·International Journal of Cardiology·Dimitris KardassisKristjan Karason
Apr 29, 2011·The New England Journal of Medicine·Hugh WatkinsCharles Redwood
Jun 15, 2011·Research in Veterinary Science·B A MaranO L Nelson
Sep 25, 2012·Journal of Feline Medicine and Surgery·Lisa M FreemanSuzanne M Cunningham
May 7, 2013·Journal of the American College of Cardiology·Iacopo OlivottoMartin S Maron
Oct 19, 2013·Journal of Veterinary Internal Medicine·J R PayneV Luis Fuentes
Apr 5, 2014·Journal of Veterinary Internal Medicine·L M FreemanB J Bulmer
Nov 21, 2014·Journal of Veterinary Internal Medicine·L M FreemanI van Hoek

❮ Previous
Next ❯

Citations

Apr 17, 2018·Journal of Veterinary Internal Medicine·Yasutomo HoriSyuhei Uchida
Feb 17, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Dan F SmelterJ Carter Ralphe
Mar 28, 2020·Clinical Genetics·Cristina Gil-OrtuñoMaría J Fernández Del Palacio
Apr 4, 2020·Journal of Veterinary Internal Medicine·Virginia Luis FuentesJoshua A Stern
Jul 29, 2020·Journal of Feline Medicine and Surgery·Ingrid Mj van HoekLisa M Freeman
Oct 26, 2021·Journal of Feline Medicine and Surgery·Mark D Kittleson, Etienne Côté

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.