The influence of comorbid anxiety on the effectiveness of Cognitive Therapy and Interpersonal Psychotherapy for Major Depressive Disorder

Journal of Affective Disorders
Suzanne C van BronswijkFrenk P M L Peeters

Abstract

Anxious depression is an important subtype of Major Depressive Disorder (MDD) defined by both syndromal (anxiety disorders) and dimensional (anxiety symptoms) criteria. A debated question is how anxiety affects MDD treatment. This study examined the impact of comorbid anxiety disorders and symptoms on the effectiveness of and dropout during Cognitive Therapy (CT) and Interpersonal Psychotherapy (IPT) for MDD. Depressed individuals were randomized to CT (n = 76) or IPT (n = 75). Outcome was depression severity measured with the Beck Depression Inventory-II (BDI-II) at the start of each therapy session, post treatment, and monthly up to five months follow-up. Anxiety disorders were assessed with the Structured Clinical Interview for DSM-IV Axis I disorders, (phobic) anxiety symptoms were assessed with Brief Symptom Inventory subscales. Approximately one third of participants had a comorbid anxiety disorder. Comorbid anxiety disorders and anxiety symptoms were associated with less favorable depression change during IPT as compared to CT in the treatment phase, but not in the trial follow-up phase. Individuals with a comorbid anxiety disorder had significantly higher treatment dropout during both treatments. Not all therapists and ...Continue Reading

Citations

May 6, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·Dana Tzur BitanDaniel Feingold
Aug 29, 2019·Journal of Neural Transmission·Isabelle HäberlingGregor Berger
Feb 6, 2020·Cadernos de saúde pública·Jesem Douglas Yamall OrellanaBernardo Lessa Horta
Jan 26, 2021·Frontiers in Psychiatry·Marcus J H HuibersNikolaos Kazantzis
Oct 30, 2021·International Journal of Methods in Psychiatric Research·Ching-I HungChing-Hui Yang

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