The influence of corticosteroids on quantitative ultrasound parameters of the calcaneus in the 1st year after renal transplantation

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Cornelis G ter MeulenAndries J Hoitsma

Abstract

Steroid-related bone loss is a recognized complication after renal transplantation. Quantitative ultrasound (QUS) of bone measures bone structure besides bone mass. We investigated the influence of corticosteroid therapy on QUS parameters in the 1st year after renal transplantation. A total of 119 renal transplant recipients were randomized to receive either a steroid-free regimen or a regimen with prednisone during 4 months. In 96 patients (steroid-free n=49, steroids n=47), dual-energy X-ray absorptiometry (DXA) parameters of the lumbar spine and the right hip, and QUS parameters of the right calcaneus were measured at baseline, 3, and 12 months after transplantation. Despite a significant difference in steroid use between the two groups, there was no statistically significant difference between the two groups in DXA and QUS parameters at any time point. BMD of the lumbar spine decreased at 3 months and recovered hereafter to the baseline value. BMD of the femoral trochanter decreased at 3 months and remained stable hereafter. The QUS parameter broadband ultrasound attenuation (BUA) was significantly lower at 12 months after transplantation compared with baseline (steroid-free -4.1+/-1.5%, steroids -2.6+/-1.5%). In contrast t...Continue Reading

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Citations

May 4, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Wojciech Pluskiewicz
May 26, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P Adamczyk
Mar 19, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Syazrah N SalamArif Khwaja
Sep 17, 2013·Clinical Transplantation·Athanasios ChristoforidisFotios Papachristou
Nov 14, 2006·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Guillermo Martínez Díaz-GuerraFederico Hawkins
May 27, 2014·Journal of Bone and Mineral Metabolism·Chrysa GkogkaFotios Papachristou
Jan 22, 2010·The Cochrane Database of Systematic Reviews·Angela C WebsterJonathan C Craig
Feb 11, 2014·Journal of the American Society of Nephrology : JASN·Sapna P IyerThomas L Nickolas
Oct 23, 2019·The Cochrane Database of Systematic Reviews·Suetonia C PalmerGiovanni Fm Strippoli
Aug 23, 2016·The Cochrane Database of Systematic Reviews·Maria C HallerAngela C Webster

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