PMID: 5905243Feb 1, 1966

The influence of cortisone on experimental viral infection. VI. Inhibition by hydrocortisone of interferon synthesis in the chick embryo

The Journal of Experimental Medicine
K M Smart, E D Kilbourne


The initial observations that cortisone may act as an inhibitor of viral interference (11, 4) are now explicable as an inhibitory effect on interferon synthesis. The suggestion that the action of interferon is also inhibited by cortisone or its analogues (6) has not been confirmed in a plaque reduction type of interferon assay system in which autointerference by the challenge inoculum is a lesser problem. In this respect, the present results are in accord with those obtained by DeMaeyer and DeMaeyer (8) with hydrocortisone in a system in which a low multiplicity (0.1) Sindbis virus infection in monolayer culture was employed with cytopathic effect (CPE) as an end-point. It has been shown that hydrocortisone is restrictive to the synthesis of interferon induced by inoculation of either infective or inactivated virus into the chick embryo, and that this inhibitory effect is temporary. However, in another study in the chick embryo, three spaced injections of hydrocortisone (0.25 mg/dose) prevented the appearance of detectable interferon during the entire 64 hr observation period following inoculation of 10(3.3) EID(50) of Lee virus (12). The importance of explicit definition of experimental conditions in assessing hormonal effects...Continue Reading


May 13, 1961·Nature·E D KilbourneB A POKORNY


Jul 1, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·E D Kilbourne
May 2, 1974·The New England Journal of Medicine·S M Sabesin, R S Koff
Nov 1, 1979·Current Problems in Pediatrics·J W St Geme
Jul 1, 1971·World's Poultry Science Journal·B M Freeman

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Hydrocortisone, (9 beta,10 alpha,11 alpha)-Isomer
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