PMID: 5905244Feb 1, 1966

The influence of cortisone on experimental viral infection. VII. Kinetics of interferon formation and its inhibition with hydrocortisone in relation to viral strain and virulence

The Journal of Experimental Medicine
K M Smart, E D KILBOURNE

Abstract

A comparative study was undertaken of the pathogenesis of infection of the allantoic sac of the chick embryo with three influenza viruses of differing virulence, and of the influence of hydrocortisone on the course of infection. Judged on the basis of earlier onset and greater degree of inflammatory response and diminished survival time of infected embryos, Mel. and Lee viruses were markedly more virulent than PR8, despite the earlier appearance of virus in PR8-infected embryos. Interferon appeared first and in greater quantity in the allantoic fluid of Lee-infected embryos and latest with PR8 infection. Thus, there was no correlation of avirulence and better interferon production with the viruses under study in the present system. Furthermore, evidence obtained suggested that Lee virus ("virulent") was most susceptible to interferon action, and also that viral synthesis in the chorioallantoic membrane with PR8 ("avirulent") persisted after the appearance of interferon. The injection of hydrocortisone within 2 hr of the initiation of infection delayed the synthesis of all three viruses; had no significant effect upon the inflammatory response; and transiently inhibited the synthesis of interferon, while prolonging the survival ...Continue Reading

References

Jan 1, 1964·Proceedings of the Society for Experimental Biology and Medicine·I GRESSER, H B DULL
Aug 22, 1964·Lancet·E F WHEELOCK, W A SIBLEY
Oct 1, 1964·Proceedings of the Society for Experimental Biology and Medicine·I GRESSER, K NAFICY
Dec 1, 1964·Proceedings of the Society for Experimental Biology and Medicine·E F WHEELOCK
May 1, 1965·Proceedings of the Society for Experimental Biology and Medicine·C HANNOUNA MACIEIRA-COELHO
Aug 1, 1949·Proceedings of the Society for Experimental Biology and Medicine·E D KILBOURNE, F L HORSFALL

Related Concepts

Chick Embryo
Hydrocortisone, (9 beta,10 alpha,11 alpha)-Isomer
Interferons
Myxoviruses
Culture Techniques

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