The influence of cost manipulation on water contrafreeloading induced by repeated exposure to quinpirole in the rat

Psychopharmacology
Michele S MilellaP Nencini

Abstract

Quinpirole (QNP), a D2/D3 dopaminergic receptor agonist, was found to elicit an apparently antieconomical drinking behavior called contrafreeloading (CFL). The perseverative operant responding observed may represent a compulsive-like behavior prompted by sensitization to the effects of QNP. In the present study, we investigated the effect of different response costs on instrumental behavior and CFL in rats repeatedly treated with QNP (0.5 mg/kg i.p.). Moreover, we studied the consummatory components of ingestive behavior in no-choice paradigms and the role of learned operant conditioning in free drinking. In experiment 1, rats were trained to perform under three different fixed ratio schedules of reinforcement (FR1, FR3, and FR10) and were given a choice between operant and free access to water. In experiment 2, rats were divided into four groups, each one resembling experiment 1 in one or more features, with no choice available and water consumption measured at an interval of 0-60 min. (a) Increasing FR significantly reduced CFL % in saline -- but not in QNP-injected groups; (b) under free-drinking conditions, QNP caused a progressive hypodipsic effect which was, however, contrasted by maintaining cues formerly contingent on o...Continue Reading

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Citations

Oct 8, 2013·CNS Spectrums·Laure-Sophie Camilla d'AngeloSamuel R Chamberlain
Apr 6, 2016·Behavioural Processes·Christopher A Podlesnik, Corina Jimenez-Gomez
Oct 28, 2017·Evolutionary Psychology : an International Journal of Evolutionary Approaches to Psychology and Behavior·Michael J Frederick, Sarah E Cocuzzo
Oct 9, 2020·Perspectives on Behavior Science·Erin B RasmussenEthan Hemmelman

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