Oct 1, 1989

The influence of cutting the pancreatic nerve plexus on exocrine function in the pancreas of rats

Gastroenterologia Japonica
Y Kinami, H Sakuma


This study was performed to clarify changes in protein synthesis and exocrine enzymes of the pancreas after cutting the pancreatic nerve plexus of Wistar rats. The rats were divided into two groups, consisting of a group that underwent cutting of the pancreatic nerve plexus (neurotomy group) and a group that underwent a sham operation (control group). 3H-leucine uptake in the pancreatic protein fraction of the neurotomy group at 3, 5 and 7 days after the operation was significantly lower than that of the control group (P less than 0.05-0.01), and this low uptake returned to the normal range at 14 days. Amylase, lipase and trypsin values in pancreatic tissue of the neurotomy group decreased during the period of from 1 to 7 days, and there were significant differences in the values of the respective enzymes at 5 or 7 days between the neurotomy and the control group (P less than 0.05). Thereafter, all enzyme values increased to within the normal range. Upon examination of pancreatic blood flow using a microsphere, the neurotomy group showed a significant reduction at 7 days compared with the control group (P less than 0.05), and thereafter exhibited recovery of blood flow. These results indicate that after cutting the pancreatic n...Continue Reading

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August Rats
Regional Blood Flow
Rat-Bite Fever
Autonomic Nervous System

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