The influence of dexamethasone on behaviorally conditioned immunomodulation and plasma corticosterone

Brain, Behavior, and Immunity
A W KusnecovM G King

Abstract

Utilizing a conditioned taste aversion paradigm we have previously shown that rats re-exposed to a saccharin solution previously paired with cyclophosphamide (CY) demonstrate significantly reduced in vitro mitogen-induced spleen cell proliferation and IgM secretion assessed 24 h after saccharin re-exposure. In this report treatment of similarly conditioned rats with dexamethasone (DEX) either before conditioning or before re-exposure abrogated the conditioned modulation of pokeweed mitogen (PWM)-induced spleen cell proliferation. The finding that DEX pretreatment on the conditioning day was as effective in abrogating the conditioned response as DEX treatment prior to the test day does not support pituitary-adrenal mediation of the conditioned immusuppressive effect following re-exposure of conditioned animals to the CS. There was no significant conditioned immunosuppression observed with respect to PHA- and Con A-induced proliferation and the influence of DEX on these parameters could not be assessed. The effect on PWM-induced IgM production was inconclusive since the reduced IgM response among conditioned animals was of only borderline significance.

References

Apr 1, 1976·Behavioral Biology·J W HennessyS Levine
Jan 1, 1979·International Journal of Immunopharmacology·F L Shand
Jan 1, 1979·International Journal of Immunopharmacology·R Pownall, M S Knapp
Jan 1, 1979·International Journal of Immunopharmacology·R AderL J Grota
Dec 1, 1976·Journal of Comparative and Physiological Psychology·R Ader
Jul 1, 1975·Journal of Comparative and Physiological Psychology·M E CarrollJ C Smith
Jan 1, 1987·Annals of the New York Academy of Sciences·H V PeekeV I Reus
Jan 1, 1986·Annual Review of Physiology·C L Rivier, P M Plotsky
Jan 1, 1987·Immunology Letters·A J HusbandR Brown
Mar 1, 1987·Brain, Behavior, and Immunity·D BovbjergR Ader
Jan 1, 1986·Physiology & Behavior·C A O'Reilly, J H Exon
Sep 1, 1987·Brain, Behavior, and Immunity·L J GrotaN Cohen
Jan 1, 1987·Physiology & Behavior·H V PeekeM Salfi
Jan 1, 1984·Endocrine Reviews·M E Keller-Wood, M F Dallman
Aug 1, 1982·Pharmacology, Biochemistry, and Behavior·A B Cairnie, K E Leach

❮ Previous
Next ❯

Citations

Dec 1, 1991·Pharmacology, Biochemistry, and Behavior·S C HeinrichsG F Koob
Dec 1, 1991·Brain, Behavior, and Immunity·P M GrochowiczK M Bowen
Jul 8, 1999·The International Journal of Neuroscience·R N HiramotoV K Ghanta
Jul 1, 1993·The International Journal of Neuroscience·B M MarkovićB D Janković

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.