[The influence of dexamethasone on pain after lumbar disc surgery. A double-blind study.].

Der Schmerz
F Brandt, H Kretschmer

Abstract

Patients operated because of lumbar disc herniations (104 patients) were included in a randomized double-blind study analyzing the influence of dexamethasone versus placebo on postoperative drug requirements and the pain score on the visual analogue scale. High doses of dexamethasone had been administered: 40 mg i.v. on the night before the operation; 8 mg intraoperatively topical perineural application; 8 mg i.v. in the evening of the day of operation; 2x8 mg i.m. on days 1 and 2 postoperatively; 2x4 mg i.m. on days 3 and 4; 4 mg po on day 5 and 6 postoperatively. A significant decrease in the requirement for analgesics was found in the drug-treated group, particularly male patients, and also an impressive reduction in the lumbar pain score. In conclusion, there was good alleviation of sciatic pain in the dexamethasone-treated group of females during the 1st week after operation, but we found no evidence that the agent tested had an influence on the clinical outcome 1 month following the operation.

References

May 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·S L Hong, L Levine
Dec 1, 1975·Journal of Neurology, Neurosurgery, and Psychiatry·L N Green
Jan 1, 1986·Agents and Actions·K BruneN Müller
Jun 16, 1973·British Medical Journal·T F DilkeR Grahame
Jun 1, 1955·Southern Medical Journal·K G JONES, H C BARNETT
Jan 1, 1951·Acta Orthopaedica Scandinavica·O LINDAHL, B REXED

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Citations

Mar 1, 1992·Der Schmerz·M Tryba
Jan 1, 1990·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·G KehrerH J Bretschneider

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