The Influence of Dexmedetomidine on Ultrasound-induced Pulmonary Capillary Hemorrhage in Rats

Ultrasound in Medicine & Biology
Douglas L MillerKrishnan Raghavendran

Abstract

The use of xylazine, a veterinary sedative, with ketamine for rat anesthesia has been shown to enhance the pulmonary capillary hemorrhage (PCH) effect of diagnostic ultrasound. This study was undertaken to assess whether the sedative/analgesic dexmedetomidine, commonly used in the intensive care unit, can also enhance ultrasound-induced PCH. Female Sprague Dawley rats were anesthetized with various combinations of ketamine plus xylazine or dexmedetomidine. The dosage of dexmedetomidine was reduced for some groups to doses relevant to human clinical usage. The right thorax of all rats was shaved and depilated for ultrasound transmission and the rats were scanned with diagnostic ultrasound using a 7.6-MHz linear array in a 38°C de-gassed water bath. There was no significant difference in PCH results for the recommended anesthetic dosages of ketamine plus xylazine and ketamine plus 500 μg/kg dexmedetomidine. The varied doses of dexmedetomidine enhanced the PCH, even for the lowest dose of 4 μg/kg, equivalent to a low human dose of 0.64 μg/kg. There was no significant difference in PCH for 500 μg/kg dexmedetomidine with or without ketamine. Further research is needed to identify and characterize other factors that may modify the pa...Continue Reading

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Mar 4, 2014·Microvascular Research·Douglas L MillerKrishnan Raghavendran
Jan 24, 2015·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Douglas L MillerKrishnan Raghavendran
Mar 10, 2015·Ultrasound in Medicine & Biology·Douglas L MillerKrishnan Raghavendran
Apr 8, 2015·Anesthesia Progress·Joseph A GiovannittiJames J Crawford

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Citations

Apr 28, 2016·Ultrasound in Medicine & Biology·Douglas L MillerKrishnan Raghavendran
Feb 10, 2018·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Douglas L MillerKrishnan Raghavendran
Dec 24, 2019·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Douglas L MillerJason Nomura
Aug 29, 2020·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Douglas L MillerZhihong Dong

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