The influence of dietary peptide inhibitors of angiotensin-converting enzyme on the hypotensive effects of enalapril

Journal of Pharmaceutical Health Care and Sciences
Machiko WatanabeFumio Itagaki

Abstract

Enalapril is an antihypertensive medicine that inhibits angiotensin I-converting enzyme (ACE). The present study investigated interactions between enalapril and a fermented milk product (FMP) containing the ACE-inhibitory peptides, Val-Pro-Pro (VPP) and Ile-Pro-Pro (IPP). Single-dose and long-term (6-week) in vivo studies were used to investigate the effects of enalapril and FMP on blood pressure in spontaneously hypertensive rats. Single-dose oral administration of concomitant enalapril and FMP (VPP, IPP: 3.5 mg/kg) produced a lower antihypertensive effect than enalapril monotherapy. However, this effect was not observed in animals administered a lower dose of FMP (VPP, IPP: 1.75 mg/kg) along with enalapril. In rats administered enalapril concomitantly with a fish protein product (FPP) containing a different ACE inhibitory peptide (Leu-Lys-Pro-Asn-Met), significant attenuation of the antihypertensive effect was also observed 1 and 2 h after administration, as compared to enalapril monotherapy. During a 6-week oral administration study, the enalapril monotherapy group showed significant antihypertensive effects compared to those observed in the controls on day 28. Oral administration of enalapril and FMP, with a 1-h interval be...Continue Reading

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Citations

Jul 30, 2020·Journal of Food Biochemistry·Ganiyu ObohAdeolu Alex Adedapo
Dec 4, 2020·European Journal of Pharmacology·Bilal ÇakırTugba Tunali-Akbay
Aug 22, 2018·Journal of Agricultural and Food Chemistry·Beatriz MirallesIsidra Recio

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