Abstract
Enalapril is an antihypertensive medicine that inhibits angiotensin I-converting enzyme (ACE). The present study investigated interactions between enalapril and a fermented milk product (FMP) containing the ACE-inhibitory peptides, Val-Pro-Pro (VPP) and Ile-Pro-Pro (IPP). Single-dose and long-term (6-week) in vivo studies were used to investigate the effects of enalapril and FMP on blood pressure in spontaneously hypertensive rats. Single-dose oral administration of concomitant enalapril and FMP (VPP, IPP: 3.5 mg/kg) produced a lower antihypertensive effect than enalapril monotherapy. However, this effect was not observed in animals administered a lower dose of FMP (VPP, IPP: 1.75 mg/kg) along with enalapril. In rats administered enalapril concomitantly with a fish protein product (FPP) containing a different ACE inhibitory peptide (Leu-Lys-Pro-Asn-Met), significant attenuation of the antihypertensive effect was also observed 1 and 2 h after administration, as compared to enalapril monotherapy. During a 6-week oral administration study, the enalapril monotherapy group showed significant antihypertensive effects compared to those observed in the controls on day 28. Oral administration of enalapril and FMP, with a 1-h interval be...Continue Reading
References
Jun 1, 1995·Journal of Dairy Science·Y NakamuraT Takano
Apr 1, 1995·Journal of Dairy Science·Y NakamuraT Takano
May 24, 1995·Biochimica Et Biophysica Acta·P W SwaanJ J Tukker
Mar 1, 1996·Bioscience, Biotechnology, and Biochemistry·Y NakamuraT Takano
Nov 1, 1996·The American Journal of Clinical Nutrition·Y HataT Takano
Dec 1, 1996·The Journal of Nutrition·O MasudaT Takano
Dec 22, 1999·Immunopharmacology·H Fujita, M Yoshikawa
Mar 29, 2001·Bioscience, Biotechnology, and Biochemistry·S AraiT Hirahara
May 10, 2002·Bioscience, Biotechnology, and Biochemistry·Makoto SatakeMakoto Shimizu
Jun 6, 2002·The Journal of Dairy Research·Marika SipolaMarja-Leena Nurminen
Jan 24, 2003·The American Journal of Clinical Nutrition·Leena SeppoRiitta Korpela
Jun 4, 2004·Journal of Human Hypertension·J TuomilehtoA Nissinen
Aug 4, 2004·American Journal of Hypertension·Shunsaku MizushimaHirotsugu Ueshima
Aug 12, 2005·Journal of the American College of Nutrition·Kotaro AiharaYasunori Nakamura
Aug 24, 2005·The British Journal of Nutrition·Seiichi MizunoNaoyuki Yamamoto
Dec 21, 2005·American Journal of Hypertension·Tiina JauhiainenRiitta Korpela
Dec 29, 2005·Journal of Medicinal Food·Jun SanoYasunori Nakamura
Sep 9, 2006·Life Sciences·Toshiro MatsuiKiyoshi Matsumoto
Dec 19, 2007·Hypertension·Mariëlle F EngberinkJohanna M Geleijnse
Jun 20, 2008·Nutrition·Jia-Ying XuChun Chang
Aug 21, 2008·The Journal of Pharmacology and Experimental Therapeutics·Ilka KnütterMatthias Brandsch
Sep 26, 2008·Journal of Molecular Recognition : JMR·A S Pina, A C A Roque
Dec 26, 2008·Food & Nutrition Research·Are Hugo Pripp
Sep 3, 2010·Journal of Human Hypertension·A F G CiceroC Borghi
Jan 12, 2011·Heart and Vessels·Tatsuhiko HirotaMasafumi Kitakaze