The influence of diethyl-m-toluamide (DEET) on the percutaneous absorption of permethrin and carbaryl

Toxicology and Applied Pharmacology
Ronald E BaynesJ E Riviere

Abstract

Simultaneous exposure to DEET and permethrin was recently proposed to be associated with the "Gulf War Syndrome." However, no studies have reported the percutaneous absorption of DEET and permethrin when applied simultaneously to the skin as a mixture, the relevant route of exposure in the Persian Gulf. The present study quantitates percutaneous absorption of DEET and permethrin after coadministration to rodent and pig skin in vitro. Dosing solutions were also prepared with either acetone, dimethyl sulfoxide (DMSO), or ethanol to compare vehicle effects on percutaneous absorption of permethrin and DEET. The influence of DEET on carbaryl absorption and dermal disposition was also assessed in pig studies to statistically demonstrate DEET effects in acetone or DMSO and different solvent concentrations. Topical application of permethrin + DEET resulted in absorption of DEET (1-20% dose), but no permethrin. Permethrin (1.2-1.7% dose) was detected only when mouse skin was dosed solely with permethrin, a finding suggesting that DEET decreased permethrin absorption. DEET also inhibited carbaryl absorption in acetone mixtures, but had no effect on DMSO mixtures. Irrespective of solvent, DEET did not enhance carbaryl penetration into ski...Continue Reading

References

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Citations

Feb 18, 2003·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Aqel W Abu-Qare, Mohamed B Abou-Donia
Mar 26, 2003·Journal of Toxicology and Environmental Health. Part a·Jim E RiviereNancy A Monteiro-Riviere
May 27, 2006·Journal of Toxicology and Environmental Health. Part a·Eman M El-Masry, Mohamed B Abou-Donia
Jul 10, 2013·International Journal of Oncology·Magdalena C KowalczykZbigniew Walaszek
Mar 8, 2005·Drug Metabolism Reviews·Ernest Hodgson, Randy L Rose
Feb 16, 2008·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·A W Abu-Qare, M B Abou-Donia
May 15, 2004·The Journal of Pharmacy and Pharmacology·Xiaochen GuFrank J Burczynski
Dec 25, 2009·Journal of Applied Toxicology : JAT·Mai A NgoHoward I Maibach
Mar 23, 2005·Toxicology and Applied Pharmacology·Arjun SanthanamGerald B Kasting
Aug 16, 2005·Regulatory Toxicology and Pharmacology : RTP·Harrie E BuistCees de Heer
Aug 1, 2008·Journal of Occupational and Environmental Hygiene·Gerald B KastingVarsha D Bhatt
Oct 19, 2007·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·F SorgeUNKNOWN Société française de pédiatrie
May 10, 2019·Pest Management Science·Daniel R Swale, Jeffrey R Bloomquist
Sep 11, 2020·Journal of Veterinary Pharmacology and Therapeutics·Wolfgang Bäumer, Ronald Baynes
Dec 28, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Kevin G McGarryRobert A Moyer
Jan 3, 2020·Journal of Occupational and Environmental Medicine·Matthew M ScarpaciSusan P Proctor

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