The Influence of Different Disease States on Rituximab Pharmacokinetics.

Current Drug Metabolism
Xiaoxing WangPengmei Li

Abstract

The anti-CD20 antibody rituximab, which promotes the selective depletion of CD20 positive B cells, was the first targeted therapy that was approved for the treatment of B-cell malignancies, and it is now widely prescribed in both malignant and non-malignant, immune-related diseases. However, the cause of its various clinical responses in certain diseases, have not been clearly elucidated. The variabilities in inter-individual pharmacokinetic and the emerging evidence of the relationships between pharmacokinetic and pharmacodynamic may provide a better understanding of this drug. We searched and summarized the latest published articles on rituximab pharmacokinetic profiles and the pharmacokinetic/pharmacodynamic models in different patient populations, including B-cell malignancies, rheumatoid arthritis, ANCA-associated vasculitis, and glomerular kidney diseases. Most pharmacokinetic data are drawn from clinical studies in oncology clinical practice. Body weight, gender, and antigen-related factors are proven to be the key factors affecting rituximab pharmacokinetics. In addition, the positive exposure-response relations were reported, which provide encouraging evidence for individualized therapies. While in immune disorders, es...Continue Reading

References

Nov 18, 1998·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N L BerinsteinD Shen
Apr 7, 2000·Journal of the American Society of Nephrology : JASN·Jean-Philippe HaymannJean-Daniel Sraer
Jan 28, 2004·Annual Review of Pharmacology and Toxicology·Monica GandhiTerrence F Blaschke
Apr 28, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K TobinaiUNKNOWN IDEC-C2B8 Japan Study Group
Sep 25, 2004·Journal of Pharmaceutical Sciences·Evelyn D LoboJoseph P Balthasar
Feb 14, 2006·Biochemical Pharmacology·Donald E Mager
Apr 14, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M D Pescovitz
Aug 24, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H GenbergG Tydén
Aug 26, 2006·Nature Clinical Practice. Rheumatology·Catherine B Driver, Michael H Weisman
Sep 4, 2007·Journal of Clinical Pharmacology·Ferdinand BreedveldBrian E Davies
Mar 14, 2008·Seminars in Arthritis and Rheumatism·Roy M Fleischmann
Sep 12, 2008·Clinical Pharmacology and Therapeutics·W WangJ P Balthasar
Oct 31, 2008·Multiple Sclerosis : Clinical and Laboratory Research·H F Petereit, A Rubbert-Roth
Aug 7, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·N KamarL Rostaing
Aug 8, 2009·Fundamental & Clinical Pharmacology·Hélène BlascoChantal Le Guellec
Mar 31, 2010·Seminars in Hematology·George J Weiner
Jan 12, 2012·Journal of Clinical Pharmacology·Jing LiJennifer Visich
Apr 19, 2012·Haematologica·Ulrich JägerUNKNOWN Arbeitsgemeinschaft Medikamentöse Tumortherapie (AGMT) Investigators
Feb 26, 2013·British Journal of Clinical Pharmacology·Florent PuissetJacques Pourrat
May 30, 2013·British Journal of Clinical Pharmacology·Nicolas AzzopardiBéatrice Birmelé
Jul 3, 2013·Journal of Clinical Pharmacology·Brittney V RobertsMelanie S Joy
Jan 18, 2014·British Journal of Clinical Pharmacology·David Rey ArponJennifer H Martin
Feb 15, 2014·Nature Reviews. Drug Discovery·Toli Koutsokeras, Tina Healy
May 14, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antonio SalarGayane Tumyan
Jun 1, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Christophe BardinJos Beijnen
Jun 15, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Nicolas WidmerAlain Astier
Nov 19, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael PfreundschuhNiels Murawski
Sep 21, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Koichi Kamei, Kenji Ishikura
Jun 23, 2016·Cancer Chemotherapy and Pharmacology·Vikram GotaHari Menon

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.