The influence of different management systems and age on intestinal morphology, immune cell numbers and mucin production from goblet cells in post-weaning pigs

Veterinary Immunology and Immunopathology
D C BrownZ B Johnson

Abstract

At time of weaning, the immune system in piglets is not fully mature resulting in reduced growth and increased mortality. Early-weaned pigs transported to a segregated early weaning (SEW) facility have enhanced performance and gut development compared to conventional (CONV) pigs which may be due, in part, to decreased pathogen challenge. To gain further insight into SEW enhanced performance and gut development, gut samples from pigs weaned at 19+/-2 days were assessed during the post-weaning (PW) period. The numbers of cells expressing CD2, CD4, CD8, and CD172 (the 74-22-15 (SWC3) antibody is now known to be specific for CD172), MHC class II, and CD25 were quantified using immunohistochemistry. Additionally, samples of duodenum, jejunum, and ileum were evaluated for the production of neutral, acidic, and sulfuric mucins from goblet cells and morphological measurements were also made. No effects due to the management systems alone were observed for any of the parameters. However, there were interactive effects of age/time post-weaning and management system on the immune cells as well as on the mucin secreting goblet cells. There were no differences in gut morphology between SEW and CONV reared pigs.

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Citations

Jan 5, 2014·Developmental and Comparative Immunology·Benoît LevastHenri Salmon
Aug 25, 2009·Veterinary Immunology and Immunopathology·Helle R Juul-MadsenBirthe M Damgaard
May 13, 2009·Research in Veterinary Science·Margret TuchschererTorsten Viergutz
Oct 5, 2007·Comparative Immunology, Microbiology and Infectious Diseases·G S JensenI Yoon
Aug 22, 2007·Journal of Animal Science·M S Gómez-CondeR Carabaño
Jan 1, 2014·Animals : an Open Access Journal From MDPI·Mhairi A SutherlandJohn J McGlone
Jul 3, 2020·Frontiers in Immunology·Jayne E WiardaCrystal L Loving
Sep 21, 2018·Frontiers in Nutrition·Sylvia BrugmanPeter A H M Bakker
Mar 9, 2019·Frontiers in Veterinary Science·Xia XiongYanhong Liu
Dec 5, 2019·Animals : an Open Access Journal From MDPI·Silvia Clotilde ModinaAlessia Di Giancamillo
May 6, 2021·Animals : an Open Access Journal From MDPI·Xiaoyuan WeiJiangchao Zhao
Jun 2, 2021·Journal of Animal Science·Lucas A RodriguesDaniel A Columbus

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