The influence of different peritoneal dialysis fluids on the in vitro activity of ampicillin, daptomycin, and linezolid against Enterococcus faecalis

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
M KussmannW Poeppl

Abstract

Intraperitoneal administration of antibiotics is recommended for the treatment of peritoneal dialysis-related peritonitis. However, little data are available on a possible interference between peritoneal dialysis fluids and the activity of antimicrobial agents. Thus, the present in vitro study set out to investigate the influence of different peritoneal dialysis fluids on the antimicrobial activity of ampicillin, linezolid, and daptomycin against Enterococcus faecalis. Time-kill curves in four different peritoneal dialysis fluids were performed over 24 h with four different concentrations (1 × MIC, 4 × MIC, 8 × MIC, 30 × MIC) of each antibiotic evaluated. Cation-adjusted Mueller-Hinton broth was used as the comparator solution. All four peritoneal dialysis fluids evaluated had a bacteriostatic effect on the growth of Enterococcus faecalis. Compared to the cation-adjusted Mueller-Hinton broth comparator solution, the antimicrobial activity of all antibiotics tested was reduced. For ampicillin and linezolid, no activity was found in any peritoneal dialysis fluid, regardless of the concentration. Daptomycin demonstrated dose-dependent activity in all peritoneal dialysis fluids. Bactericidal activity was observed at the highest con...Continue Reading

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Citations

Sep 28, 2018·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Wolfgang PoepplGottfried Reznicek
Nov 11, 2018·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Laure Peyro Saint PaulThierry Lobbedez
Sep 9, 2016·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Martin WiesholzerWolfgang Poeppl
Sep 30, 2016·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Laure Peyro Saint PaulThierry Lobbedez
Sep 30, 2016·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Manuel KussmannMartin Wiesholzer
Jun 11, 2016·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Philip Kam-Tao LiDavid W Johnson
Mar 17, 2018·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Manuel KussmannMartin Wiesholzer
May 10, 2019·Clinical Journal of the American Society of Nephrology : CJASN·Cheuk-Chun Szeto, Philip Kam-Tao Li
Jul 8, 2017·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M KussmannG Reznicek
Aug 18, 2021·International Journal of Pediatrics & Adolescent Medicine·Saeed M AlZabliKhawla A Rahim

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