The influence of different plasticizers and polymers on the mechanical and thermal properties, porosity and drug permeability of free shellac films

Drug Development and Industrial Pharmacy
Basel Qussi, Wolfgang G Suess

Abstract

The effect of triethyl citrate (TEC) and different molecular weights and concentrations of polyethylene glycol (PEG), in addition to the effect of different water-soluble polymers and dispersions at different levels, hydroxypropyl methylcellulose (HPMC), methylcellulose (MC), carbomer 940, polyvinyl alcohol (PVA), ethyl cellulose (EC), on the mechanical and thermal properties, drug permeability, and porosity of free shellac films were investigated. Shellac films were cast from aqueous solutions, and their mechanical properties were studied by tensile test. Thermal analyses were performed using differential scanning calorimetry (DSC). The results showed that the addition of plasticizer caused a decrease in both elastic modulus and glass transition temperature (T(g)) and an increase in elongation at break of free shellac films. This effect was related to the concentrations of plasticizers. Different molecular weights of PEGs have different plasticization mechanisms.Moreover, the incorporation of different amounts of HPMC, MC, or carbomer in free shellac films caused an increase in the flexibility, decrease in T(g), and a marked increase in drug permeability of free shellac films, whereas the addition of PVA caused a decrease in f...Continue Reading

References

Sep 1, 1975·The Journal of Pharmacy and Pharmacology·M Donbrow, M Friedman
Apr 17, 1999·International Journal of Pharmaceutics·C Wu, J W McGinity
Sep 16, 1999·International Journal of Pharmaceutics·N SarisutaS Puttipipatkhachorn
May 5, 2000·International Journal of Pharmaceutics·M MuramatsuY Kanaya
Aug 28, 2001·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·S Mattsson, C Nyström
Nov 24, 2001·International Journal of Pharmaceutics·Ewart T ColeDominique Cadé
May 25, 2002·Drug Development and Industrial Pharmacy·Linda A Felton, James W McGinity
Jan 28, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Nantharat PearnchobRoland Bodmeier

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Citations

Jan 7, 2010·Drug Development and Industrial Pharmacy·Stuart C Porter, Linda A Felton
May 28, 2011·Drug Development and Industrial Pharmacy·Hollie F BruceLinda A Felton
Jun 20, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Sontaya LimmatvapiratManee Luangtana-Anan
May 4, 2011·Molecular Nutrition & Food Research·Anett OehmePeter Schreier
Feb 9, 2008·Praxis der Kinderpsychologie und Kinderpsychiatrie·Mechthild Alpermann, Gabriele Koch
Jul 13, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Scott M KrullRajesh N Davé
Oct 28, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Parameswara Rao VuddandaSitaram Velaga
Mar 25, 2015·Nanomaterials·Charu Vashisth RohatgiNamita Roy Choudhury
Oct 7, 2020·Pharmaceutical Development and Technology·Umesh KesturJohn Fiske
Mar 30, 2021·International Journal of Pharmaceutics·Juliane Fjelrad ChristfortAnette Müllertz
Jul 2, 2019·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Min HanHong Yuan
Nov 26, 2010·Journal of Agricultural and Food Chemistry·Manee Luangtana-ananSontaya Limmatvapirat
Oct 1, 2021·AAPS PharmSciTech·Manee Luangtana-AnanSontaya Limmatvapirat
Dec 12, 2021·Scientific Reports·Alexandre PoulinGustav Nyström

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