The influence of dipeptide composition on protein thermostability

FEBS Letters
Yanrui DingWenbo Xu

Abstract

In this work, the influence of dipeptide composition on protein thermostability was studied. After comparing the normalized dipeptide composition between mesophilic proteins and (hyper)thermophilic proteins, we concluded that when organism optimal growth temperature increased, for archaeal proteins, the compositions of VK, KI, YK, IK, KV, KY, and EV increased significantly and the compositions of DA, AD, TD, DD, DT, HD, DH, DR, and DG decreased significantly; and for bacterial proteins, the compositions of KE, EE, EK, YE, VK, KV, KK, LK, EI, EV, RK, EF, KY, VE, KI, KG, EY, FK, KF, FE, KR, VY, MK, WK, and WE increased significantly and the compositions of WQ, AA, QA, MQ, AW, QW, QQ, RQ, QH, HQ, AD, AQ, WL, QL, HA, and DA decreased significantly. So these characteristic dipeptides are correlative to protein thermostability. At the same time, the influence of single amino acid composition on protein thermostability was also studied for comparison. We found that the influence of single amino acid composition could be deduced from the influence of dipeptide composition. So we thought that the influence of dipeptide composition on protein thermostability is larger than the influence of amino acid composition. The characteristic dipep...Continue Reading

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Citations

Dec 15, 2010·Extremophiles : Life Under Extreme Conditions·Debamitra ChakravortySanjukta Patra
Nov 6, 2015·International Journal of Molecular Sciences·Jingqun AoXinhua Chen
Dec 26, 2015·International Journal of Molecular Sciences·Shunfang Wang, Shuhui Liu
Nov 4, 2010·Journal of Microbiological Methods·Hao Lin, Wei Chen
Dec 10, 2013·Genomics, Proteomics & Bioinformatics·Geetha Govindan, Achuthsankar S Nair
Jul 15, 2020·Biotechnology and Bioengineering·Zhong YuFangang Meng
Aug 22, 2020·Journal of Biomolecular Structure & Dynamics·Liang WangXiao Zhang
Mar 28, 2017·BMC Bioinformatics·Prabina Kumar MeherAtmakuri Ramakrishna Rao
May 21, 2020·Frontiers in Bioengineering and Biotechnology·Changli FengYanjuan Li

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