The influence of dizocilpine on the reserpine-induced behavioral and neurobiological changes in rats

Neuroscience Letters
Zhen-Yong GaoHai-Yun Xu

Abstract

Clinical studies have demonstrated that a single dose of ketamine produces complete remission within 24h in some depression patients. The ability of ketamine to produce fast-acting antidepressant-like effects in animal models depends on rapid synthesis of brain-derived neurotrophic factor (BDNF). Here we examined effects of a single dose dizocilpine, a non-competitive NMDA receptor antagonist, on the behavioral and neurobiological changes in rats treated with a single high dose reserpine, which is a monoamine re-uptake blocker and depletes monoamines in the brain with the outcome of depression-like symptoms in animals. A single high dose reserpine (4.0mg/kg) was given to rats intraperitoneally. Forty-eight hours later, the rats showed depressive symptoms as evidenced by decreased locomotor activity in the open field and increased immobility time in the forced swim test. Meanwhile, the treatment decreased BDNF levels and neurogenesis in the hippocampus. Pretreatment of a single dose dizocilpine (0.30mg/kg), however, prevented all the reserpine-induced changes, except for GluN1 subunit. These results are suggestive of the involvement of neurogenesis and BDNF in the rapid-acting antidepressant-like behavioral effects of the NMDA r...Continue Reading

References

Mar 1, 1992·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·J MajH Sowińska
Aug 21, 1990·European Journal of Pharmacology·R Trullas, P Skolnick
Nov 1, 1965·The American Journal of Psychiatry·J J Schildkraut
Nov 1, 1995·Pharmacology, Biochemistry, and Behavior·R T LayerP Skolnick
Nov 27, 2001·British Medical Bulletin·V A Vaidya, R S Duman
May 10, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Renata C DutraMaria A B F Vital
Sep 22, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Lêda S B GarciaJoão Quevedo
Jun 19, 2012·Biological Psychiatry·Marije Aan Het RotSanjay J Mathew
Dec 5, 2013·Neuroscience and Biobehavioral Reviews·Ian MaharJosé N Nobrega
May 9, 2014·Brain Structure & Function·Maryam GhafariGert Lubec
Dec 3, 2014·Current Opinion in Pharmacology·Ege T Kavalali, Lisa M Monteggia
Apr 8, 2015·Behavioural Brain Research·Urszula DoboszewskaGabriel Nowak

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