The influence of dopamine agonists and antagonists on indomethacin lesions in stomach and small intestine in rats

European Journal of Pharmacology
P SikirićL Kalogjera

Abstract

Dopamine agents (saline in control groups) were coadministered with indomethacin by either single or repeated application. The ulcerogenic effect (erosions and/or ulcers) of repeated given indomethacin on gastric mucosa differed clearly from that on intestinal mucosa. The effect on intestinal mucosa was markedly greater than after a single dose. The effects of dopamine agents appeared to be more consistent. Domperidone and haloperidol, given as single or repeated doses, strongly aggravated both the gastric and intestinal lesions. Bromocriptine and amantadine had a protective effect. The adverse effects of both dopamine antagonists (increased after repeated administration) were strongly inhibited by the simultaneous administration of either bromocriptine or amantadine. The involvement of the dopamine system (central or peripheral) in the mechanisms that maintain gastric (probably related to cytoprotection also) and intestinal mucosa integrity is therefore suggested.

References

Oct 27, 1979·Lancet·S Szabo
Dec 1, 1987·European Journal of Pharmacology·P SikirićI Udovicić
Nov 12, 1986·European Journal of Pharmacology·P SikirićI Rotkvić
Jan 1, 1985·Gastroenterology·F W LeungP H Guth
Jul 1, 1985·Digestive Diseases and Sciences·J C Meeroff
May 28, 1985·European Journal of Pharmacology·P SikirićA Marović
Nov 15, 1973·Biochemical Pharmacology·L Landsberg, H L Taubin
Jan 1, 1974·Dermatologica·W G van Ketel, B Goedhart-van Dijk
Dec 1, 1967·Acta Physiologica Scandinavica·B FalckN O Sjöberg
Mar 1, 1983·Drugs·K W Somerville, M J Langman
Jun 1, 1983·Naunyn-Schmiedeberg's Archives of Pharmacology·R KullmannA Konopatzki
Dec 10, 1984·Life Sciences·D E HernandezA J Prange
Apr 22, 1983·European Journal of Pharmacology·J D KohliL I Goldberg
Nov 1, 1994·Reproductive Toxicology·F Rosa

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Citations

Dec 1, 1992·Digestive Diseases and Sciences·I RotkvićP Sikirić
Sep 1, 1990·Digestive Diseases and Sciences·G B Glavin, S Szabo
Dec 1, 1994·Journal of Gastroenterology·N KawakitaY Saitoh
Oct 12, 2001·Journal of Physiology, Paris·P SikiricI Sjekavica
Sep 14, 2001·Journal of Veterinary Pharmacology and Therapeutics·V Herak-PerkovićM Pogacnik
Jul 31, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Bethany K Wilson, Ellen J Hess

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