The influence of dopamine agonists and antagonists on indomethacin lesions in stomach and small intestine in rats

European Journal of Pharmacology
P SikirićL Kalogjera


Dopamine agents (saline in control groups) were coadministered with indomethacin by either single or repeated application. The ulcerogenic effect (erosions and/or ulcers) of repeated given indomethacin on gastric mucosa differed clearly from that on intestinal mucosa. The effect on intestinal mucosa was markedly greater than after a single dose. The effects of dopamine agents appeared to be more consistent. Domperidone and haloperidol, given as single or repeated doses, strongly aggravated both the gastric and intestinal lesions. Bromocriptine and amantadine had a protective effect. The adverse effects of both dopamine antagonists (increased after repeated administration) were strongly inhibited by the simultaneous administration of either bromocriptine or amantadine. The involvement of the dopamine system (central or peripheral) in the mechanisms that maintain gastric (probably related to cytoprotection also) and intestinal mucosa integrity is therefore suggested.


Oct 27, 1979·Lancet·S Szabo
Dec 1, 1987·European Journal of Pharmacology·P SikirićI Udovicić
Nov 12, 1986·European Journal of Pharmacology·P SikirićI Rotkvić
Jan 1, 1985·Gastroenterology·F W LeungP H Guth
Jul 1, 1985·Digestive Diseases and Sciences·J C Meeroff
May 28, 1985·European Journal of Pharmacology·P SikirićA Marović
Nov 15, 1973·Biochemical Pharmacology·L Landsberg, H L Taubin
Jan 1, 1974·Dermatologica·W G van Ketel, B Goedhart-van Dijk
Dec 1, 1967·Acta Physiologica Scandinavica·B FalckN O Sjöberg
Mar 1, 1983·Drugs·K W Somerville, M J Langman
Jun 1, 1983·Naunyn-Schmiedeberg's Archives of Pharmacology·R KullmannA Konopatzki
Dec 10, 1984·Life Sciences·D E HernandezA J Prange
Apr 22, 1983·European Journal of Pharmacology·J D KohliL I Goldberg
Nov 1, 1994·Reproductive Toxicology·F Rosa

❮ Previous
Next ❯


Dec 1, 1992·Digestive Diseases and Sciences·I RotkvićP Sikirić
Sep 1, 1990·Digestive Diseases and Sciences·G B Glavin, S Szabo
Dec 1, 1994·Journal of Gastroenterology·N KawakitaY Saitoh
Oct 12, 2001·Journal of Physiology, Paris·P SikiricI Sjekavica
Sep 14, 2001·Journal of Veterinary Pharmacology and Therapeutics·V Herak-PerkovićM Pogacnik
Jul 31, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Bethany K Wilson, Ellen J Hess

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.