The influence of dose on the pattern of conjugation of phenol and 1-naphthol in non-human primates

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
R MehtaP Millburn

Abstract

1. The pattern of conjugation of phenol and 1-naphthol was investigated in several primates; three Old World species (rhesus, cynomolgus, patas monkeys), two New World species (capuchin, tamarin), and two prosimians (bushbaby, tree shrew). 2. Following intra-muscular phenol or 1-naphthol (10 mg/kg), sulphation was the major conjugation in the Old World monkeys and prosimians, whereas glucuronidation predominated in the New World species. 3. In rhesus and cynomolgus monkeys, sulphation decreased as dose increased, but remained the major conjugation with both substrates at dose levels of 0.01 to 25 mg/kg. 4. In the capuchin, the conjugation pattern of phenol changed markedly as dose increased; at 0.01 and 1 mg/kg sulphation was the major conjugation, whereas at 10 and 25 mg/kg glucuronidation predominated. With 1-naphthol only small amounts of sulphate were excreted; glucuronic acid conjugation was the major metabolism at all four dose levels. 5. The importance of considering both substrate and dose when making inter-species comparisons, particularly with man, is discussed.

References

Jun 1, 1976·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·P S SeverR T Williams
Jan 1, 1974·Journal of Medical Primatology·R L Smith, R T Williams
Jan 1, 1972·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·I D CapelR T Williams
Oct 1, 1974·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J W BridgesR T Williams
Jul 25, 1972·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·M O JamesM Reidenberg
Dec 1, 1967·The Biochemical Journal·J W BridgesR T Williams

Citations

Jan 1, 1981·European Journal of Drug Metabolism and Pharmacokinetics·L AllanR F Palmer
Feb 15, 1984·Biochemical Pharmacology·M D DohertyM T Smith
Jun 23, 1999·Toxicology Letters·J W Boles, C D Klaassen
Feb 1, 1983·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·R Nagel, K Urich
Jan 1, 1983·Drug Metabolism Reviews·P G Dayton, J E Sanders
Sep 17, 2013·Molecular Nutrition & Food Research·Toshiyuki NakamuraJ Terao
Jun 1, 1987·British Journal of Clinical Pharmacology·S M RogersM L Orme
Mar 1, 1984·Biochemical Pharmacology·E M Gibby, G M Cohen
Dec 15, 1981·Biochemical Pharmacology·E M GibbyG M Cohen
Jun 27, 2000·The Journal of Nutrition·M K Piskula
Jan 1, 1984·Critical Reviews in Toxicology·B Clark, D A Smith
Jun 1, 1993·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J Jodynis-Liebert

Related Concepts

Anthropoidea
Callitrichinae
Dose-Response Relationship, Drug
Erythrocebus patas
Euoticus
Macaca fascicularis
Macaca mulatta
Naphthols
Phenols
Shrews

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