The influence of drug-excipient and drug-polymer interactions on butt adhesive strength of ranitidine hydrochloride film-coated tablets

Drug Development and Industrial Pharmacy
N SarisutaKrisana Srikummoon

Abstract

The influence of fillers and polymeric films on adhesive strength of hydroxypropyl methylcellulose (HPMC) and Eudragit E100 films coated on ranitidine HCl tablets containing either spray-dried rice starch (SDRS) or lactose monohydrate as fillers after storage at 45 degrees C/75% RH for four weeks was investigated by the use of butt adhesion technique. The adhesive strength of film-coated tablets of fillers without drug was found to slightly decrease after storage. In contrast, the adhesive strength of drug-containing film-coated tablets significantly reduced, the degree of which was higher for Eudragit E100 than HPMC. Physicochemical characterization by employing differential scanning calorimetry (DSC) and diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) revealed that the drug was obviously incompatible with lactose and possibly mild interaction with Eudragit E100 was suggested. The results indicated that the adhesive strength of film-coated tablets would be affected not only by the drug-excipient interaction, but also by the drug-polymeric film interaction.

References

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Sep 16, 1999·International Journal of Pharmaceutics·N SarisutaS Puttipipatkhachorn
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Oct 7, 2005·Drug Development and Industrial Pharmacy·M L VuebaMaria Eugénia Pina

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Citations

Sep 17, 2015·Pharmaceutical Development and Technology·Makiko FujiiYoshiteru Watanabe
Oct 30, 2012·Expert Opinion on Drug Delivery·Seema ThakralDipak K Majumdar
Nov 16, 2013·Drug Development and Industrial Pharmacy·Namon HirunVimon Tantishaiyakul
Apr 1, 2011·Journal of Pharmaceutical Sciences·Changkang PanMichael Motto
May 16, 2014·Journal of Pharmaceutical Sciences·Joyann A MarksKevin J Edgar
Oct 14, 2014·International Journal of Pharmaceutics·Ikram Ullah KhanThierry F Vandamme
Jun 19, 2012·Pharmaceutical Research·Ajit S NarangSherif Badawy
Sep 13, 2017·AAPS PharmSciTech·Mittal A DarjiS Narasimha Murthy

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