The Influence of Early Measurements Onto the Estimated Kidney Dose in [(177)Lu][DOTA(0),Tyr(3)]Octreotate Peptide Receptor Radiotherapy of Neuroendocrine Tumors

Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging
Andreas DelkerGuido Böning

Abstract

Multiple measurements have been required to estimate the radiation dose to the kidneys resulting from [(177)Lu]DOTATATE therapy for neuroendocrine tumors. The aim of this study was to investigate the influence of early time-point measurement in the renal dose calculation. Anterior/posterior whole-body planar scintigraphy images were acquired at approx. 1, 24, 48, and 72 h after administration of [(177)Lu]DOTATATE. Furthermore, we acquired planar 1-bed dynamic recordings in 12 frames (5 min each) during the first hour. We assessed kidney exposure with a three-phase model consisting of a linear increase to the maximum within the initial minutes p.i., followed a bi-exponential decline. This three-phase-model served as reference for evaluating accuracy of dose estimates in 105 kidneys calculated by conventional mono-exponential fitting of the final three and four whole-body images. Mean effective half-life times for the reference model were 25.8 ± 12.0 min and 63.9 ± 17.6 h, predicting a mean renal dose of 5.7 ± 2.1 Gy. The effective half-life time was 46.3 ± 15.4 h for the last four and 63.3 ± 17.0 h for the last three data points. The mean start of the first whole-body measurement was 1.2 ± 0.1 h p.i. The ratio of fast to slow ph...Continue Reading

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Citations

Sep 1, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Andreas DelkerGuido Böning
Jul 6, 2018·EJNMMI Physics·Anna SundlövKatarina Sjögreen Gleisner
May 13, 2020·EJNMMI Physics·Nanette FreedmanEinat Even-Sapir
Aug 31, 2018·EJNMMI Research·Daphne Merel Valerie HuizingMarcellus Petrus Maria Stokkel
Oct 13, 2015·Physics in Medicine and Biology·Johan GustafssonKatarina Sjögreen Gleisner
Jan 15, 2021·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Theresa P DevasiaMatthew J Schipper

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