The Influence of Education and Apolipoprotein ε 4 on Mortality in Community-Dwelling Elderly Men and Women

Journal of Aging Research
Duke Appiah, Richard N Baumgartner

Abstract

We investigated the risk of death in relation to the apolipoprotein ε4 allele and evaluated how it interacts with education in 504 elderly adults (mean age 73 years, 65.3% women) who were enrolled in 1993 into the New Mexico Aging Process Study. During 9 years of follow-up, apolipoprotein ε2 appeared to be associated with a lower risk for all-cause mortality (hazard ratio (HR) = 0.73, 95% confidence interval (CI): 0.30-1.71) compared to apolipoprotein ε3 carriers in models adjusted for age, sociodemographic variables, medical conditions, adiposity, and lifestyle factors. The apolipoprotein ε4 allele conferred almost a threefold elevated risk of mortality (HR = 2.76, CI: 1.42-5.37). An interaction between education and apolipoprotein e4 (p=0.027) was observed with the HR of mortality among e4 carriers compared to noncarriers being 1.59 (0.64-3.96) for those with ≥college education; 6.66 (1.90-23.4) for those with some college or trade; and 14.1 (3.03-65.6) for participants with ≤high school education. No significant interaction was identified between apolipoprotein E genotype and cognitive function for mortality risk. These findings suggest that genetic (apolipoprotein ε4) and environmental (education) factors act interactively ...Continue Reading

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Citations

Sep 15, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Caleb E Finch, Alexander M Kulminski
Oct 5, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Rachel DanknerAngela Chetrit
Oct 24, 2018·International Journal of Molecular Sciences·Francesco VillaAnnibale Alessandro Puca
Oct 2, 2020·International Journal of Molecular Sciences·Marta DossenaAnnibale Alessandro Puca

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Methods Mentioned

BETA
genotyping

Software Mentioned

SAS

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