The Influence of Electron Beam Sterilization on In Vivo Degradation of β-TCP/PCL of Different Composite Ratios for Bone Tissue Engineering

Micromachines
Jin-Ho KangYunzhi Peter Yang

Abstract

We evaluated the effect of electron beam (E-beam) sterilization (25 kGy, ISO 11137) on the degradation of β-tricalcium phosphate/polycaprolactone (β-TCP/PCL) composite filaments of various ratios (0:100, 20:80, 40:60, and 60:40 TCP:PCL by mass) in a rat subcutaneous model for 24 weeks. Volumes of the samples before implantation and after explantation were measured using micro-computed tomography (micro-CT). The filament volume changes before sacrifice were also measured using a live micro-CT. In our micro-CT analyses, there was no significant difference in volume change between the E-beam treated groups and non-E-beam treated groups of the same β-TCP to PCL ratios, except for the 0% β-TCP group. However, the average volume reduction differences between the E-beam and non-E-beam groups in the same-ratio samples were 0.76% (0% TCP), 3.30% (20% TCP), 4.65% (40% TCP), and 3.67% (60% TCP). The E-beam samples generally had more volume reduction in all experimental groups. Therefore, E-beam treatment may accelerate degradation. In our live micro-CT analyses, most volume reduction arose in the first four weeks after implantation and slowed between 4 and 20 weeks in all groups. E-beam groups showed greater volume reduction at every time...Continue Reading

References

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Citations

Mar 25, 2021·Scientific Reports·Yunzhi Peter YangMichael J Gardner
Jun 8, 2021·Biomechanics and Modeling in Mechanobiology·Camille Perier-MetzSara Checa
Apr 29, 2021·Tissue Engineering. Part a·Toshiyuki KawaiYunzhi P Yang
Jul 28, 2021·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Alexander StahlYunzhi P Yang

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