The influence of equol on the hypothalamic-pituitary-thyroid axis and hepatic lipid metabolic parameters in adult male rats

Life Sciences
Panida LoutchanwootHubertus Jarry

Abstract

Equol, the principal active metabolite of soy-derived phytoestrogen daidzein, has well-known estrogenic actions. Results of several studies indicate that equol may also have anti-androgenic activities. However, mechanisms of action of equol on hypothalamic-pituitary-thyroid axis (HPTA) and hepatic lipid metabolism in adult male rats have not been determined yet. Equol at two doses of 100 and 250mg/kgbodyweight(BW)/day was orally gavaged for 5days to groups of 4-month-old male rats. As a positive anti-androgenic control group, animals received 100mg of pure anti-androgenic drug flutamide/kgBW/day. Circulating concentrations of thyroid hormones and lipids, and expression levels of genes underlying HPTA function were determined by radioimmunoassay and TaqMan® real-time reverse transcription polymerase chain reaction, respectively. Flutamide significantly decreased relative prostate weight, whereas equol did not. Both equol and flutamide caused a significant increase in relative liver weights, and decreases in plasma levels of total tetraiodothyronine (T4) and triiodothyronine (T3), whereas free T4 and T3 concentrations were not reduced. Equol caused the marked down-regulation of hypothalamic thyrotropin-releasing hormone mRNA expr...Continue Reading

References

Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·K J KollerR T Zoeller
Jun 9, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·N Sathyamoorthy, T T Wang
Sep 7, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·John C O'ConnorGregory S Ladics
Sep 25, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Daniel R Doerge, Hebron C Chang
Mar 28, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·E BoweyI Rowland
Apr 16, 2004·The Journal of Steroid Biochemistry and Molecular Biology·Partha RoyIlpo T Huhtaniemi
Jun 29, 2004·World Journal of Gastroenterology : WJG·Ji-Feng WangPei-Heng Li
Apr 7, 2007·Menopause : the Journal of the North American Menopause Society·Dominik RachońWolfgang Wuttke
Sep 14, 2007·Climacteric : the Journal of the International Menopause Society·D RachońW Wuttke
Jan 12, 2008·Analytical and Bioanalytical Chemistry·Toine F H BoveeAd A C M Peijnenburg
May 12, 2009·Journal of Clinical Biochemistry and Nutrition·Yoko TakahashiTakashi Ide
Dec 8, 2009·The Journal of Nutritional Biochemistry·Frank A SimmenRonald L Prior
Jan 15, 2011·Reproductive Biology and Endocrinology : RB&E·Trent D LundEdwin D Lephart
May 31, 2011·Regulatory Toxicology and Pharmacology : RTP·Susanne N KolleBennard van Ravenzwaay
Jun 26, 2012·The Journal of Clinical Endocrinology and Metabolism·Furong WangJiajun Zhao

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.