The influence of established and new antiepileptic drugs on visual perception. 1. A placebo-controlled, double-blind, single-dose study in healthy volunteers

Epilepsy Research
B J SteinhoffW Paulus

Abstract

The influence of single oral dosages of carbamazepine (CBZ), valproic acid, vigabatrin (VGB), lamotrigine (LTG), gabapentin (GBP), and losigamone (LSG) on visual perception was investigated in ten healthy volunteers according to a double-blind, placebo-controlled, cross-over study design. The test battery comprised visual acuity, the Lanthony-D-15-désaturé colour perception test, increment, postadaptation and transient tritanopia threshold measurements, perception threshold assessment for monochromatic and chromatic gaussian dots, monochromatic gratings and gratings of differing spatial frequency, and critical flicker fusion tests with various stimuli. The only consistent and partly significant effects were seen after VGB and GBP. After VGB, increment, postadaptation and transient tritanopia thresholds and the critical flicker fusion increased, whereas GBP led to a somewhat converse profile. The other tests were not influenced consistently by any antiepileptic drug (AED). We conclude that: (i) gamma-amino-butyric acid-(GABA)-related properties as under the prototype drug VGB result in specific alterations of the transient tritanopia phenomenon which is consistent with the physiological hypothesis for this retinal paradigm based...Continue Reading

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Citations

Jan 3, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·James W WhelessStephen D Collins
May 8, 2004·Seizure : the Journal of the British Epilepsy Association·Emma J Roff HiltonTim Betts
Apr 17, 2001·Cephalalgia : an International Journal of Headache·A J Shepherd
Jul 10, 2002·Epilepsia·Sampsa VanhataloMarja-Liisa Granström
Jul 13, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A VerrottiP Iannetti
May 25, 2005·Cephalalgia : an International Journal of Headache·A J Shepherd
Dec 19, 2002·The British Journal of Ophthalmology·S L HoskingA K Gupta
Jul 21, 2001·CNS Drugs·R Kälviäinen, I Nousiainen
May 7, 2010·CNS Drugs·Sami Richa, Jean-Claude Yazbek
Apr 8, 2014·Ophthalmology·John Z XieUNKNOWN Multi-Ethnic Pediatric Eye Disease Study Group
Feb 6, 2007·Journal of Cataract and Refractive Surgery·Hema Shankar, Konrad Pesudovs
Apr 24, 2016·Cephalalgia : an International Journal of Headache·Alex J Shepherd, Ramiro M Joly-Mascheroni
Apr 7, 2016·Korean Journal of Ophthalmology : KJO·Ju Young KimYong Sung You

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