The influence of excipients on drug release from hydroxypropyl methylcellulose matrices

Journal of Pharmaceutical Sciences
Marina Levina, A R Rajabi-Siahboomi

Abstract

The influence of commonly used excipients, spray-dried lactose (SDL), microcrystalline cellulose (MCC), and partially pregelatinized maize starch (Starch 1500) on drug release from hydroxypropyl methylcellulose (HPMC, hypromellose) matrix system has been investigated. A model formulation contained 30%w/w drug, 20%w/w HPMC, 0.5%w/w fumed silica, 0.25%w/w magnesium stearate, and 49.25%w/w filler. Chlorpheniramine maleate and theophylline were used as freely (1 in 4) and slightly (1 in 120) water-soluble drugs, respectively. It was found that for both drugs, addition of 20 to 49.25%w/w Starch 1500 resulted in a significant reduction in drug release rates compared to when MCC or SDL was used. The study showed that using lactose or microcrystalline cellulose in the formulations resulted in faster drug release profiles. Partially pregelatinized maize starch contributed to retardation of both soluble and slightly soluble drugs. This effect may be imparted through synergistic interactions between Starch 1500 and HPMC and the filler actively forming an integral part within the HPMC gel structure.

References

May 1, 1995·The Journal of Pharmacy and Pharmacology·C H LiuM T Sheu
Sep 19, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·V LenaertsR Marchessault
Dec 24, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·M V VelascoA R Rajabi-Siahboomi
Jul 6, 2000·International Journal of Pharmaceutics·R EspinozaL Villafuerte

❮ Previous
Next ❯

Citations

Oct 16, 2010·Pharmaceutical Research·Luciana A CoráJosé Ricardo Aruda Miranda
Dec 12, 2012·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Songa Ambedkar SunilKolapalli Venkata Ramana Murthy
Nov 19, 2008·AAPS PharmSciTech·Praveen S Hiremath, Ranendra N Saha
Mar 31, 2010·AAPS PharmSciTech·Tamara Gonçalves-AraújoIsidoro Caraballo
Nov 18, 2015·Drug Development and Industrial Pharmacy·Pompilia Ispas-SzaboMircea Alexandru Mateescu
Oct 19, 2013·Drug Development and Industrial Pharmacy·Faiezah A A MohamedAli R Rajabi-Siahboomi
Apr 11, 2008·Drug Development and Industrial Pharmacy·Musa El-BarghouthiAdnan Badwan
Oct 26, 2012·Drug Development and Industrial Pharmacy·M L VuebaM E Pina
Jun 27, 2009·Drug Development and Industrial Pharmacy·Maria Esther ZugastiMaría Cristina Martínez-Ohárriz
Mar 17, 2011·Drug Development and Industrial Pharmacy·Alvaro GoyanesRamón Martínez-Pacheco
Jul 19, 2012·Drug Development and Industrial Pharmacy·Kiran YadavAnand Kumar Srivastava
Jul 13, 2007·Journal of Pharmaceutical Sciences·Taravat GhafourianAli Nokhodchi
Sep 14, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Qilei ZhangMichael Mantle
Apr 19, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Cristina MaderueloJosé M Lanao
Mar 2, 2011·International Journal of Pharmaceutics·Kalyana PingaliFernando Muzzio
Feb 15, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Anna ViridénAnette Larsson
Feb 23, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·P R Laity, R E Cameron
Jun 5, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Feng ZhangN A Watson
Oct 22, 2016·Advanced Pharmaceutical Bulletin·Christe Sonia Mary, Sasikumar Swamiappan
Feb 24, 2017·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Alexandru GavanIoan Tomuta
Jun 22, 2017·International Journal of Pharmaceutics·Diego CaccavoAnette Larsson
Aug 23, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Zhi-Mei MiaoRen-Xi Zhuo
Jun 15, 2005·Analytical Chemistry·R K Gilpin, L A Pachla
Aug 31, 2021·Advanced Drug Delivery Reviews·Benedict BrownKofi Asare-Addo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Dipasree Sinha Roy, Bhagwan D Rohera
European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Jayanti NerurkarM O Park
© 2021 Meta ULC. All rights reserved