PMID: 8957142Dec 2, 1996Paper

The influence of familial and non-familial factors on the association between major depression and substance abuse/dependence in 1874 monozygotic male twin pairs

Drug and Alcohol Dependence
N LinM T Tsuang

Abstract

The co-occurrence of major depression (MD) with alcohol and illicit substance abuse/dependence (A/D) has been repeatedly observed. However, prior research has been unable to determine whether or not the co-occurrence is a result of familial vulnerability or non-familial influences. The present study examines the association of the lifetime diagnosis of MD with alcohol, cannabis, amphetamine, cocaine, and sedative A/D (DSM-III-R criteria) before and after controlling for familial factors in a non-clinical sample of 1874 middle aged, monozygotic male twin pairs. A lifetime diagnosis of MD was significantly associated with lifetime diagnosis of alcohol and illicit substance A/D prior to accounting for familial factors (odds ratios: 1.8-4.5). After employing a co-twin analytical technique to control for familial factors, a lifetime diagnosis of MD remained significantly associated only with lifetime diagnoses of cannabis, amphetamine and sedative A/D (odds ratios: 2.3-10.9). These results suggest that the association between MD and alcohol A/D is influenced by familial factors. In contrast, the association between MD and illicit substances of A/D is largely explained by non-familial factors.

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Citations

Mar 18, 2000·Clinical Psychology Review·J D Swendsen, K R Merikangas
Jun 11, 2011·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Sonali JhanjeeKushal Jain
Jul 27, 2006·The American Journal on Addictions·Lori L DavisA John Rush
Feb 28, 2008·Journal of Traumatic Stress·Mark W MillerTerence M Keane
Feb 24, 2006·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Laura ManninenTiina Laatikainen
Jun 3, 2008·The Journal of Behavioral Health Services & Research·Michael PrendergastYih-Ing Hser
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Feb 19, 2008·Current Opinion in Psychiatry·Lori DavisElizabeth Frazier
Jun 5, 2003·Addiction·Thoroddur BjarnasonEva Stergar
May 4, 2017·Behavior Genetics·M SmolkinaM T Lynskey
Jan 25, 2021·Clinical Psychology Review·Jasmine Turna, James MacKillop
Mar 8, 2019·Diabetes Research and Clinical Practice·Jessie J WongJessica Y Breland

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