The influence of fasting on liver sulfhydryl groups, glutathione peroxidase and glutathione-S-transferase activities in the rat

Journal of Physiology and Biochemistry
T SzkudelskiK Szkudelska

Abstract

Sulfhydryl groups, glutathione peroxidase (GPx) and glutathione-S-transferase (GST) are important elements of the antioxidant defence in the organism. The efficacy of their antioxidant action is influenced by many factors. In this work, the effect of fasting on total, protein-bound and nonprotein sulfhydryl groups and on the activity of liver and serum GPx and GST in rats were determined. Male Wistar rats were divided into two groups: non-fasted and 18-hour fasted. In fasted animals liver content of nonprotein sulfhydryl groups (represented predominantly by reduced glutathione; GSH) was diminished by 22% in comparison to non-fasted group, whereas total and protein-bound -SH groups were unaffected. The activity of liver and serum GPx was unchanged in food deprived rats. In these animals the activity of GST in serum was reduced by 26%. Fasting had no significant effect on the activity of GST in the liver. Our results demonstrate that in rats deprived of food for 18 hours liver and serum GPx and GST are not involved in protection against action of reactive oxygen species formed during fasting. The observed drop in the content of liver nonprotein sulfhydryl groups without concomitant rise in the activity of GPx and GST indicates th...Continue Reading

References

Jul 1, 1979·Toxicology and Applied Pharmacology·D PessayreJ P Benhamou
Jan 1, 1979·Digestion·D PessayreJ P Benhamou
Jan 1, 1992·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·M J TuñónJ A Madrid
Mar 15, 1990·Toxicology and Applied Pharmacology·M Shimizu, S Morita
May 1, 1981·The Journal of Nutrition·E S ChoL D Stegink
Jun 1, 1982·The Journal of Pharmacology and Experimental Therapeutics·T SatohH Kitagawa
Aug 1, 1993·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·P T LiuD V Parke
Jun 1, 1993·Toxicology and Applied Pharmacology·D W Potter, T B Tran
Jul 9, 1999·Postgraduate Medical Journal·E SzaleczkyA Somogyi
Mar 4, 2000·Transplantation Proceedings·B NardoA Cavallari
Aug 26, 2000·The Journal of Nutrition·I GrattaglianoE Altomare
Jun 28, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M Kirsch, H De Groot
Aug 25, 2001·Journal of Physiology and Biochemistry·C GambelungheS Rufini
Dec 26, 2001·The Journal of Pharmacology and Experimental Therapeutics·James V BrucknerSrinivasa Muralidhara
Feb 1, 1964·Clinica Chimica Acta; International Journal of Clinical Chemistry·W G DUNCOMBE

❮ Previous
Next ❯

Citations

Jan 17, 2007·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Rosalind A LeggattRobert H Devlin
Feb 14, 2012·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·José Pablo Vázquez-MedinaRudy M Ortiz
May 17, 2014·PloS One·Susanne Jenni-EiermannDavid Costantini
Aug 26, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Michael KyriakidesMuireann Coen
Sep 1, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Marcos Roberto de OliveiraSeyed Mohammad Nabavi
Oct 13, 2012·Environmental Toxicology and Chemistry·Heli RouttiGeir Wing Gabrielsen
Jun 17, 2015·Oxidative Medicine and Cellular Longevity·Marcos Roberto de Oliveira
Nov 2, 2016·The Journal of Experimental Biology·Quentin SchullJean-Patrice Robin
Apr 27, 2013·The Journal of Experimental Biology·José Pablo Vázquez-MedinaRudy M Ortiz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Applied Physiology and Occupational Physiology
P Di SimplicioM L Formento
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Benjamin ReyClaude Duchamp
European Journal of Biochemistry
Kim Bartlett, Simon Eaton
Annual Review of Pharmacology and Toxicology
Thomas W KenslerShyam Biswal
© 2021 Meta ULC. All rights reserved