PMID: 2505698Sep 1, 1989Paper

The influence of fibronectin administration on the incidence of sepsis and septic mortality in severely injured patients. The Medical College of Georgia Fibronectin Research Group

Annals of Surgery
A R MansbergerR Shulman

Abstract

Eighty-five trauma patients between the ages of 18 and 55, with American College of Surgeon's (ACOS) trauma scores greater than or equal to 7 were entered into a double-blind, randomized, placebo-controlled study to assess the efficacy of prophylactic fibronectin (Fn) administration on clinical course, sepsis development, and septic mortality. Patients were randomized on admission to receive purified human virus-inactivated Fn or placebo control (human serum albumin, HSA). Fn or HSA was administered on a daily basis if and when the patient was Fn deficient (less than 75% normal). When a Fn deficiency was not evident, the patient received saline. Seventy one patients developed Fn deficiencies during their initial clinical course: 36 received Fn, 35 received HSA. Fourteen patients did not develop a Fn deficiency after trauma and thus received only saline. Analysis of admission data demonstrated no significant differences between the three groups with respect to extent of injury (injury severity score, ACOS trauma score) or physiologic assessments of organ function (serum creatinine, bilirubin, lactic acid). On day 1 after trauma, Fn levels were shown to correlate with other plasma proteins and cellular components (range of r valu...Continue Reading

References

Oct 1, 1978·Annals of Surgery·W A ScovillS R Powers
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Nov 1, 1981·American Journal of Surgery·A B RobbinsA R Mansberger

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Citations

Nov 1, 1992·The Journal of Surgical Research·M NagelschmidtG H Engelhardt
May 12, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ofelia M Martinez-EstradaGianfranco Bazzoni

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