The influence of foetal prednisone exposure on the cortisol levels in the offspring

Clinical Endocrinology
Florentien D O de SteenwinkelRadboud J E M Dolhain

Abstract

Pregnant women suffering from autoimmune disease use glucocorticoids. Glucocorticoids can partly diffuse to the foetus and may influence the development of the foetal hypothalamic-pituitary-adrenal axis, especially in early stage of pregnancy. The objective was to investigate whether prednisone exposure in utero influences the cortisol levels of the prepubertal children. Mothers participated in a prospective cohort study on rheumatoid arthritis (RA) and pregnancy. Children were exposed (n = 44) or nonexposed (n = 65) to prednisone in utero. Salivary cortisol levels were taken from all children during 1 day: at awakening, 30 min after awakening, 1 p.m. and bedtime. Cortisol levels between groups were also analysed using area under the curve (AUC), cortisol awakening response (CAR) and slope. The mean age (SD) of the children was 6·98 (1·23). The difference in mean (SD) cortisol level at '1 p.m.' was 5·42 nm (4·08) in the prednisone-exposed and 3·97 nm (4·00) in the nonexposed (P = 0·03). Prednisone-exposed children had a higher AUC (β = 13·28; P = 0·02), even after correction for RA disease activity. No differences were found on CAR, slope or blood pressure. The cortisol levels of the nonexposed were more similar to the age-spec...Continue Reading

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Citations

May 17, 2014·Annals of the Rheumatic Diseases·Jenny BrouwerRadboud J E M Dolhain
Dec 25, 2015·Best Practice & Research. Clinical Rheumatology·Hilal Ince-Askan, Radboud J E M Dolhain
May 31, 2019·Annals of the Rheumatic Diseases·Hilal Ince-AskanRadboud J E M Dolhain
May 21, 2014·Annals of the New York Academy of Sciences·Monika Ostensen
Nov 9, 2020·Journal of Reproductive Immunology·Qianyi HuangXiaoqian Fu

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