The Influence of Formulation and Excipients on Propranolol Skin Permeation and Retention

BioMed Research International
Cristina PadulaP Santi

Abstract

The objective of this work was to study in vitro propranolol permeation and skin retention after topical application of different semisolid vehicles, with the final aim of developing new topical formulations intended for the treatment of infantile hemangioma, able to produce therapeutic drug levels in the skin, avoiding systemic absorption. Propranolol ointments, creams, and gels were prepared and tested on pig skin, an accepted model of human skin. From the results obtained in the present work it is clear that the permeation of propranolol across the skin is a poor predictor of its skin retention, at least in the time-frame considered. With an application time of 4 h, reasonably close to the permanence time of a semisolid formulation on the skin surface, the best performance (high retention and low skin penetration) was obtained with lipophilic formulations, in particular with a lipophilic cream containing olive oil. Hydrophilic formulations, such as gels, are characterized by a significant permeation across the skin, probably leading to systemic side effects, accompanied by a limited skin retention. Overall, the results obtained in the present work pose the basis for the development of new topical formulations, containing pro...Continue Reading

References

Aug 1, 1993·Journal of Pharmaceutical Sciences·J I AdemolaH I Maibach
Jun 13, 1998·The Journal of Pharmacy and Pharmacology·G Ktistis, I Niopas
Feb 29, 2000·International Journal of Pharmaceutics·P ModamioE L Mariño
May 23, 2001·Advanced Drug Delivery Reviews·Y N Kalia, R H Guy
Aug 28, 2001·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·K MoserR H Guy
May 2, 2002·The Journal of Investigative Dermatology·Robert P ChilcottSimon T Bradley
Feb 23, 2005·Dermatology : International Journal for Clinical and Investigative Dermatology·Christian Surber, Eric W Smith
Jun 14, 2008·The New England Journal of Medicine·Christine Léauté-LabrèzeAlain Taïeb
Aug 5, 2009·Journal of Pharmaceutical Sciences·Francesco CilurzoLuisa Montanari
Dec 7, 2011·Pediatric Dermatology·Karin Kunzi-Rapp
Apr 21, 2012·Journal of the American Academy of Dermatology·Guangqi XuRan Huo
Dec 5, 2012·Pharmaceutical Research·Doungdaw ChantasartS Kevin Li
Dec 29, 2012·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Lie WangYiqing Li
Jun 19, 2013·Annales de dermatologie et de vénéréologie·A Mouhari-ToureP Pitche
Sep 17, 2013·British Journal of Clinical Pharmacology·Yin LouHong-hong Li
Jan 23, 2014·Molecular Pharmaceutics·Francesco CilurzoPaola Minghetti
Jul 1, 2014·International Journal of Pharmaceutics·Meera Gujjar, Ajay K Banga
Dec 18, 2014·World Journal of Pediatrics : WJP·Markus SchneiderPeter Ruef
Dec 21, 2014·Acta Dermatovenerologica Alpina, Pannonica, Et Adriatica·Maja KovačevićAndrija Stanimirović
Jan 16, 2015·Annals of Plastic Surgery·Steven A OvadiaSeth R Thaller
Feb 20, 2015·Journal of Pharmaceutical Sciences·Qian ZhangS Kevin Li
Jul 28, 2016·International Journal of Pharmaceutics·Isabella TelòSara Nicoli
Aug 18, 2016·Skin Pharmacology and Physiology·Antonella CasiraghiPaola Minghetti
Dec 2, 2017·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Anita Rotter, Zilda Najjar Prado de Oliveira

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Citations

Jun 3, 2021·Dermatologic Therapy·Angela FiloniDomenico Bonamonte
Jul 23, 2021·Colloids and Surfaces. B, Biointerfaces·Cristina da Costa Bernardes AraújoFlávia Almada do Carmo

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