The influence of gastric pentadecapeptide BPC 157 on acute and chronic ethanol administration in mice

European Journal of Pharmacology
Alenka Boban BlagaicP Sikiric

Abstract

The stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, M.W.1419), which was promising in inflammatory bowel disease (PL-10, PLD-116, PL-14736, Pliva) trials, protects against both acute and chronic alcohol-induced lesions in stomach and liver, but also, given peripherally, affects various centrally mediated disturbances. Now, in male NMRI mice BPC 157 (10 pg intraperitoneally, 10 ng and 10 microg, intraperitoneally or intragastrically) (i) strongly opposed acute alcohol (4 g/kg intraperitoneally) intoxication (i.e., quickly produced and sustained anesthesia, hypothermia, increased ethanol blood values, 25% fatality, 90-min assessment period) given before or after ethanol, and (ii) when given after abrupt cessation of ethanol (at 0 or 3 or 7 h withdrawal time), attenuated withdrawal (assessed through 24 hours) after 20%-alcohol drinking (7.6 g/kg) through 13 days, with provocation on the 14th day.

Citations

Jun 8, 2011·European Journal of Pharmacology·Spomenko IlicPredrag Sikiric
Nov 26, 2009·Regulatory Peptides·Mario TudorPredrag Sikiric
Aug 19, 2007·Micron : the International Research and Review Journal for Microscopy·M MartinezF E Martinez
Apr 21, 2005·European Journal of Pharmacology·Alenka Boban BlagaicPredrag Sikiric
Aug 13, 2021·Neural Regeneration Research·Jakša VukojevicPredrag Sikirić

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