The influence of gender on the short and long-term effects of growth hormone replacement on bone metabolism and bone mineral density in hypopituitary adults: a 5-year study

Clinical Endocrinology
W M DrakeJ P Monson

Abstract

The objectives of this study were to investigate the effects of GH replacement therapy in hypopituitary adults with growth hormone deficiency (GHD) on activation of bone remodelling during dose titration and on BMD over a median of 58 months of continuous therapy. Open label study in adult patients with GHD. rhGH was commenced at dose of 0.8 IU subcutaneously daily (0.4 IU if hypertensive or glucose tolerance impaired) with subsequent dose titration based on 2 weekly measurement of serum IGF-I until levels reached the target range (between the median and upper end of the age related reference range). In patients previously commenced on GH using weight based regimens the dose of GH was adjusted during clinical follow-up in order to maintain serum IGF-I in the target range. Initial effects of GH on bone remodelling during dose titration were studied in 17 patients (8F). Long-term effects of GH were determined in a separate group of 13 GHD adults (6F) over a median period of 58 months (range 44-72). Osteoblastic activity was estimated by measuring serum bone specific alkaline phosphatase (S-BAP). BMD was determined at both lumbar spine (L2-L4) and femoral neck by dual energy X-ray absorptiometry (DEXA). During dose titration a sig...Continue Reading

References

Nov 1, 1992·Clinical Endocrinology·R C CuneoP H Sönksen
Jan 1, 1992·The Journal of Clinical Endocrinology and Metabolism·J M KaufmanM Vandeweghe
Apr 1, 1990·The Journal of Clinical Endocrinology and Metabolism·J S JohansenN E Skakkebaek
Jul 1, 1990·The Journal of Clinical Endocrinology and Metabolism·J S JohansenC Christiansen
Jun 3, 1989·Lancet·J O JørgensenJ S Christiansen
Aug 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H de BoerE A van der Veen
Sep 1, 1994·The Journal of Clinical Endocrinology and Metabolism·S E Inzucchi, R J Robbins
Mar 1, 1994·The Journal of Clinical Endocrinology and Metabolism·S J HolmesS M Shalet
Dec 1, 1993·Journal of Internal Medicine·A G JohanssonS Ljunghall
Jan 1, 1993·The Journal of Pediatric Endocrinology·G ZamboniL Tatò
Jul 1, 1993·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M C Slootweg
Feb 1, 1993·The Journal of Clinical Endocrinology and Metabolism·B A BengtssonO G Isaksson
May 1, 1993·The Journal of Clinical Endocrinology and Metabolism·D J O'HalloranS M Shalet
Dec 1, 1996·Clinical Endocrinology·S E Inzucchi, R J Robbins
Oct 23, 1997·European Journal of Endocrinology·T RosénB A Bengtsson
Mar 12, 1998·Endocrine Reviews·C OhlssonM C Slootweg
Jun 4, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M ThorénS Mohan
Nov 14, 1998·The Journal of Clinical Endocrinology and Metabolism·W M DrakeJ P Monson

❮ Previous
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Citations

Jan 22, 2011·Calcified Tissue International·Alessandro RossiniAlessandro Rubinacci
Nov 2, 2006·Pituitary·M DogaA Giustina
Aug 7, 2002·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·R Nass, M O Thorner
May 1, 2013·Nature Reviews. Endocrinology·Atil Y Kargi, George R Merriam
Jul 28, 2011·Journal of Pediatric Hematology/oncology·Silvia van den HeijkantHenriette Delemarre-van de Waal
Dec 14, 2004·Hormone Research·A Leal Cerro
Apr 26, 2008·Endocrine Reviews·Andrea GiustinaErnesto Canalis
Feb 10, 2012·European Journal of Endocrinology·Mariam ElbornssonJohan Svensson
Aug 18, 2009·European Journal of Endocrinology·Julia D J Thomas, John P Monson
Jan 16, 2007·European Journal of Endocrinology·G GötherströmJ Svensson
Apr 18, 2008·Der Internist·M Faust, C J Strasburger
Apr 13, 2010·Ultrasound in Medicine & Biology·Alessandro MussaPatrizia Matarazzo
Jul 17, 2007·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Anna G NilssonGudmundur Johannsson
Mar 7, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Clifford J Rosen, Christian Wüster
Nov 24, 2006·Clinical Endocrinology·Mette Friberg HitzPeter C Eskildsen
Jul 20, 2002·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Helen SimpsonUNKNOWN GRS Council
Jul 30, 2014·Neurologia Medico-chirurgica·Izumi FukudaAtsuhiro Ichihara
Dec 12, 2001·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·T L McCarthy, M Centrella
Nov 3, 2004·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Thor Ueland
Apr 24, 2018·Endocrine Reviews·Gherardo MazziottiAndrea Giustina
Apr 26, 2006·The Journal of Clinical Endocrinology and Metabolism·Mark E MolitchPatricia A Stephens
Feb 4, 2005·Endocrine Reviews·Johannes D VeldhuisCyril Y Bowers
Sep 1, 2011·Expert Review of Endocrinology & Metabolism·Sreedevi GuttikondaRandall J Urban
Jan 16, 2014·The Journal of Clinical Endocrinology and Metabolism·Maya BarakeNicholas A Tritos
Sep 10, 2008·Expert Opinion on Pharmacotherapy·Torben LaursenJens Sandahl Christiansen
Sep 23, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity·Nicholas A Tritos, Beverly M K Biller
Mar 22, 2012·Endocrine Reviews·Manthos G GiannoulisPeter Sonksen
Aug 9, 2001·Endocrine Reviews·W M DrakeS M Shalet
Mar 1, 2017·Sociology Compass·Corey M Abramson, Elena Portacolone
Mar 17, 2010·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·David M CookUNKNOWN American Association of Clinical Endocrinologists
Oct 24, 2003·Annals of Medicine·Antonia M Brooke, John P Monson
Nov 5, 2016·The Journal of Clinical Endocrinology and Metabolism·Maria FleseriuMary H Samuels
May 11, 2021·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Nigel GlynnAmar Agha

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