The influence of genetic polymorphisms of GSTP1 on the development of asbestosis

Journal of Occupational and Environmental Medicine
Alenka FrankoMetoda Dodic-Fikfak

Abstract

Genetic factors play an important role in the development of asbestosis. The aim of this study was to investigate whether genetic polymorphisms of glutathione S-transferase (GST) P1 represent a risk factor for this disease. The study population included 262 workers with asbestosis and 265 matched controls. Information on cumulative asbestos exposure was available. A real-time PCR based on the 5' nuclease assay was designed for the analysis of GSTP1 Ile105Val and Ala114Val polymorphisms. Asbestosis was associated with GSTP1 genotype coding for an enzyme with high conjugation capacity versus genotypes resulting in intermediate and low enzyme activity (odds ratio = 1.49, confidence interval = 1.06-2.10). The key finding of the study was that GSTP1 genotype coding for an enzyme with high conjugation capacity significantly increases the risk of developing asbestosis.

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Jun 15, 2007·Journal of Occupational and Environmental Medicine·Alenka FrankoVita Dolzan

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Citations

Dec 10, 2008·Arhiv za higijenu rada i toksikologiju·Alenka FrankoMetoda Dodic-Fikfak
Aug 29, 2013·BioMed Research International·A FrankoM Dodič-Fikfak
Jul 29, 2009·Journal of Biomedicine & Biotechnology·Alenka FrankoVita Dolzan
May 13, 2010·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·N ZendehdelM Dehghani
Dec 18, 2014·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Bridgette E GarrettTim McAfee
Feb 6, 2021·Radiology and Oncology·Alenka FrankoVita Dolzan

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