The influence of growth factors on skin wound healing in rats

Brazilian Journal of Otorhinolaryngology
Elen Carolina David João De MasiRoberta David João De Masi

Abstract

Healing is a process that restores the physical integrity of body structures. It is a dynamic, complex, multicellular process that involves the extracellular matrix, cytokines, blood cells, and growth factors. Growth factors are proteins that activate and stimulate cell proliferation through the activation of angiogenesis, mitogenesis, and gene transcription, accelerating the healing process. To assess the influence of growth factors on the healing process of wounds made on the backs of female rats compared to the control wound, through macro and microscopy. This study used 45 female Wistar rats, in which three wounds were made on the back. The first was the control wound, the second received epithelial growth factor injection, and the third received a combination of factors. Macroscopic and microscopic assessments were performed on the third, seventh, and 15th days of the experiment. For microscopic analysis, hematoxylin-eosin staining was utilized to assess the inflammatory process; vimentin, for assessment of blood vessels and fibroblasts, and Sirius Red for collagen assessment. In the macroscopic assessment, the use of growth factors resulted in faster healing and decrease of granulation tissue on days seven and 15; (80.31%...Continue Reading

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Citations

Jan 25, 2017·International Journal of Molecular Sciences·Meenakshi GaurVictoria V Lunyak
Sep 28, 2016·Experimental Dermatology·Cong LiuRong Li
Apr 4, 2019·Journal of Medicinal Food·Mitzzy F Medellín-LunaAlberto R Cervantes-Villagrana
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