The influence of halothane and thiopental on respiratory-related nerve activities in decerebrate cats

Acta Anaesthesiologica Scandinavica
A MasudaR Takeda

Abstract

The effects of halothane and thiopental on the respiratory efferent activities in the phrenic, recurrent laryngeal and hypoglossal nerves were studied in decerebrate, paralyzed and artificially ventilated cats. Inhalation of halothane (2%, 90 s) and intravenous injection of thiopental (2-3 mg/kg) produced a similar change in the breathing pattern, characterized by an increase in respiratory frequency and a decrease in the respiratory burst discharge in the three nerves studied. Depression of the respiratory activity was greatest in the hypoglossal nerve, intermediate in the recurrent laryngeal nerve, and least in the phrenic nerve. Both drugs diminished the whole power spectral densities of the three nerves. Thiopental selectively attenuated the high frequency peaks of these spectra and shifted the peak frequencies to lower values. Bilateral section of the vagus and carotid sinus nerves had no effect on the action of thiopental on the respiratory neural activities, whereas it decreased, but did not eliminate, the action of halothane. The present results demonstrate that both halothane and thiopental produce a selective depression of the upper airway motor activities, with stronger effects on the hypoglossal nerve. Effects on th...Continue Reading

References

Mar 1, 1983·British Journal of Anaesthesia·S E Judge
Mar 1, 1983·British Journal of Anaesthesia·C D Richards
Aug 1, 1984·Pflügers Archiv : European journal of physiology·F M Bennett, W M St John
Sep 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J C HwangD Bartlett
Feb 11, 1982·Brain Research·C A Richardson, R A Mitchell
Mar 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·D WeinerN S Cherniack

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Citations

Jul 7, 2000·Pharmacology & Therapeutics·A HajiM Okazaki
Aug 1, 1995·Acta Anaesthesiologica Scandinavica·A MasudaR Takeda
Jun 10, 2004·Respiratory Physiology & Neurobiology·Ralph F FregosiMakito Iizuka
Jul 3, 2013·Respiratory Physiology & Neurobiology·C J DuboisO Pierrefiche

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