PMID: 2481158Jan 1, 1987Paper

The influence of heart rate on coronary artery atherosclerosis.

Journal of Cardiovascular Pharmacology
Jay R KaplanT B Clarkson

Abstract

Elevated "casual" heart rate (HR) has been found to be an independent predictor of coronary heart disease (CHD) in human beings. The current study provides data on the association between coronary artery atherosclerosis (CAA) and naturally occurring individual differences in the casual HRs of cynomolgus macaques (Macaca fascicularis). The data demonstrate that naturally occurring differences in casual HR are related to CAA (plaque area in mm) with high HR monkeys having lesions more than twice as extensive as those of low HR monkeys (high HR; n = 7, 159 beats/min: 0.76 mm2 +/- 0.21 SD; low HR; n = 8, 133 beats/min: 0.31 mm2 +/- 0.30; t = 3.01, p less than 0.01). The data show further that the distribution of individual differences in casual HR is consistent and stable over periods of at least 12 months. Importantly, the relationship between elevated casual HR and CAA was independent of the association between an index of HR "responsivity" to stress and CAA, found in the same monkeys. Similar to a recent finding in human beings, high casual HR also was associated with significantly lowered serum concentrations of high-density lipoprotein cholesterol; differences in CAA were, however, independent of the lipid difference. The CAA ...Continue Reading

Citations

Mar 29, 2011·Journal of Women's Health·Matthew A AllisonMaurizio Trevisan
Jul 4, 2008·Psychosomatic Medicine·Carol A ShivelyThomas B Clarkson
Dec 4, 2010·Journal of the American College of Cardiology·Florian CustodisUlrich Laufs
Aug 16, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Francesca OlmettiMaria Teresa La Rovere
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Feb 1, 1989·Experimental and Molecular Pathology·K W Weingand
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Aug 28, 2007·Journal of the American College of Cardiology·Kim FoxUNKNOWN Heart Rate Working Group
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