PMID: 8603800Jan 1, 1996Paper

The influence of high and low molecular weight chitosan on colonic cell proliferation and aberrant crypt foci development in CF1 mice

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
T L TorzsasA V Rao

Abstract

The effect of dietary chitosan, a fibre of animal origin, on the induction and development of colonic precursor lesions was determined in CF1 mice. Over a 2-wk pretreatment period, one group of mice was given azoxymethane (four injections of 5 mg/kg body weight) and the other was treated with saline. Subsequent to carcinogen or saline pretreatment mice were randomized into one of three dietary groups: (i) control AIN-76 diet; (ii) control AIN-76 diet with 2% low molecular weight chitosan (LMWC); or (iii) control AIN-76 diet with 2% high molecular weight chitosan (HMWC). Mice were maintained on this diet for 6 wk. Mice fed diet containing HMWC had significant reductions in the number of aberrant crypt foci, cell proliferation, crypt height and crypt circumference in the colonic epithelium (P < 0.05). In mice given diet supplemented with LMWC there was a trend towards reduced numbers of aberrant crypts, as well as decreased crypt height and circumference. The results of this study indicate that dietary chitosan reduces the incidence of early preneoplastic markers of colon carcinogenesis, as indicated by aberrant crypts and mitotic figures and altered crypt morphometrics in the murine colon. Molecular range and viscosity of the ch...Continue Reading

References

Apr 15, 1975·International Journal of Cancer. Journal International Du Cancer·B Armstrong, R Doll
Sep 1, 1990·Journal of Occupational Medicine. : Official Publication of the Industrial Medical Association·C R Smart
Oct 1, 1985·Mutation Research·J Watabe, H Bernstein
Jul 1, 1971·Cancer·D P Burkitt
Jan 1, 1971·The American Surgeon·B P Colcock
Jan 1, 1984·Nutrition and Cancer·G E McKeown-Eyssen, E Bright-See
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D KafetzopoulosV Bouriotis

❮ Previous
Next ❯

Citations

May 19, 2011·International Journal of Nanomedicine·Jun Jie WangShu Ling Wang
Jul 31, 2013·Journal of Colloid and Interface Science·Pankaj BharmoriaArvind Kumar
Sep 23, 2011·The Journal of Nutritional Biochemistry·Andrew P NeilsonDean E Brenner
Feb 18, 2005·Biochimica Et Biophysica Acta·K V Harish Prashanth, R N Tharanathan
Jul 23, 2014·Asian-Australasian Journal of Animal Sciences·Yuanqing XuJunliang Li
Oct 23, 2004·Drug Metabolism and Pharmacokinetics·Hiroyuki TsudaMalcolm A Moore
Oct 30, 2016·Pharmacology & Therapeutics·Chatchai Muanprasat, Varanuj Chatsudthipong
Aug 23, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Hsi-Wen ChenNai-Chen Cheng
Jan 1, 2009·Journal of Dietary Supplements·Catherine UlbrichtJen Woods
Sep 21, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Anne McTiernanPaul D Lampe

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.