PMID: 3754515Feb 1, 1986Paper

The influence of hormone receptors and hormonal adjuvant therapy on disease-free survival in breast cancer: a multifactorial analysis

European Journal of Cancer & Clinical Oncology
L CaldarolaP Gaglia

Abstract

The prognostic value of estrogen (ER) and progesterone (PgR) receptor status and the influence of hormonal adjuvant therapy on disease-free survival (DFS) in breast cancer were evaluated in 680 women after radical and modified radical mastectomy. The effect of 17 variables, including clinical data, TNM, hormone receptor status, histology and adjuvant therapy, on the DFS observed was analyzed, using a multivariate proportional hazard model. Multifactorial analysis revealed that DFS was strongly related to the number of positive axillary nodes (P less than 0.001) and the histological grade of the tumor (P = 0.05). Moreover, the DFS of ER-positive patients with node involvement was significantly improved by hormonal adjuvant therapy (tamoxifen). Combination of adjuvant chemotherapy with hormonal therapy did not enhance its effectiveness. Recurrence rates of either node-negative or ER-negative patients were not affected by either adjuvant therapy. When no systemic therapy was given, no significant relationship between ER or PgR content of the tumor and the DFS was observed. These findings suggest that hormone receptor status is not an independent prognostic factor but provides reliable information on responsiveness to adjuvant horm...Continue Reading

References

Oct 1, 1983·European Journal of Cancer & Clinical Oncology·J F StewartJ L Hayward
Jan 1, 1983·Breast Cancer Research and Treatment·B Fisher
Jan 1, 1983·Breast Cancer Research and Treatment·S SaezB Asselain
Nov 14, 1981·British Medical Journal·R CrotonK Griffiths
Jan 1, 1982·Breast Cancer Research and Treatment·J P CroweW L McGuire
Feb 1, 1981·Cancer·N A SamaanR Martin

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Citations

Jan 23, 2013·Global Health Action·Nguyen H LanJohn F Stewart
May 1, 1992·The American Journal of Medicine·W W WongR R Weichselbaum
Mar 11, 1992·Critical Reviews in Oncology/hematology·D N Danforth
Jan 23, 2010·Breast Cancer Research and Treatment·Edith A PerezCathy A Andorfer
Nov 24, 2006·Journal of Marital and Family Therapy·Ryan B Seedall, Mark H Butler
Apr 1, 1992·Annals of Medicine·C P BlomqvistP Rissanen
May 1, 1991·The British Journal of Surgery·Z Rayter
Mar 1, 1988·Cancer Treatment Reviews·R J Epstein
Sep 1, 1993·Japanese Journal of Pharmacology·I KawamuraM Kohsaka

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