The Influence of Hydrogen Bonding on Sphingomyelin/Colipid Interactions in Bilayer Membranes

Biophysical Journal
Tomokazu YasudaJ Peter Slotte

Abstract

The phospholipid acyl chain composition and order, the hydrogen bonding, and properties of the phospholipid headgroup all influence cholesterol/phospholipid interactions in hydrated bilayers. In this study, we examined the influence of hydrogen bonding on sphingomyelin (SM) colipid interactions in fluid uni- and multilamellar vesicles. We have compared the properties of oleoyl or palmitoyl SM with comparable dihydro-SMs, because the hydrogen bonding properties of SM and dihydro-SM differ. The association of cholestatrienol, a fluorescent cholesterol analog, with oleoyl sphingomyelin (OSM) was significantly stronger than its association with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, in bilayers with equal acyl chain order. The association of cholestatrienol with dihydro-OSM, which lacks a trans double bond in the sphingoid base, was even stronger than the association with OSM, suggesting an important role for hydrogen bonding in stabilizing sterol/SM interactions. Furthermore, with saturated SM in the presence of 15 mol % cholesterol, cholesterol association with fluid dihydro-palmitoyl SM bilayers was stronger than seen with palmitoyl SM under similar conditions. The different hydrogen bonding properties in OSM and dihy...Continue Reading

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Citations

Mar 16, 2016·Biochimica Et Biophysica Acta·Sara García-LinaresJ Peter Slotte
May 25, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Md Abdullah Al Sazzad, J Peter Slotte
Jul 18, 2020·Scientific Reports·Masanao KinoshitaNobuaki Matsumori
Dec 2, 2020·International Journal of Molecular Sciences·Esperanza Rivera-de-TorreSara García-Linares
Apr 27, 2017·Biophysical Journal·J Peter SlotteMichio Murata
May 28, 2019·Biophysical Journal·Md Abdullah Al SazzadJ Peter Slotte
Dec 26, 2018·Biophysical Journal·Thomas K M NyholmJ Peter Slotte
Apr 6, 2021·Journal of Parkinson's Disease·Hila AvisarBoaz Lerner
May 20, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bingen G MonasterioAlicia Alonso
Jun 3, 2021·International Journal of Molecular Sciences·Brianna M QuinvilleJagdeep S Walia
Aug 3, 2021·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Anders P E Backman, Peter Mattjus
Apr 13, 2017·The Journal of Physical Chemistry. B·Eric Wang, Jeffery B Klauda
Oct 24, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Tomokazu YasudaMichio Murata
May 6, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Tania C B SantosLiana C Silva

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