The influence of hydrostatic pressure on tissue engineered bone development

Journal of Theoretical Biology
K H L NeßlerJames M Osborne

Abstract

The hydrostatic pressure stimulation of an appropriately cell-seeded porous scaffold within a bioreactor is a promising method for engineering bone tissue external to the body. We propose a mathematical model, and employ a suite of candidate constitutive laws, to qualitatively describe the effect of applied hydrostatic pressure on the quantity of minerals deposited in such an experimental setup. By comparing data from numerical simulations with experimental observations under a number of stimulation protocols, we suggest that the response of bone cells to an applied pressure requires consideration of two components; (i) a component describing the cell memory of the applied stimulation, and (ii) a recovery component, capturing the time cells require to recover from high rates of mineralisation.

References

Mar 1, 1994·Bone·M E LevenstonD R Carter
Jul 21, 1999·Journal of Biomechanical Engineering·D ZhangS C Cowin
Feb 22, 2002·Bone·N Basso, J N M Heersche
Mar 14, 2002·Biochemical and Biophysical Research Communications·Felicity R A J Rose, Richard O C Oreffo
Aug 16, 2003·Annals of Biomedical Engineering·Jiro NagatomiRena Bizios
Feb 6, 2004·Trends in Biotechnology·Ivan MartinMichael Heberer
Feb 24, 2004·Medical & Biological Engineering & Computing·M MullenderJ Klein-Nulend
Aug 18, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Erica TakaiX Edward Guo
Dec 21, 2005·Pathologie-biologie·J Klein-NulendM G Mullender
Dec 21, 2005·Pathologie-biologie·Alicia J El HajYing Yang
Sep 22, 2007·Matrix Biology : Journal of the International Society for Matrix Biology·Robyn K FuchsDavid B Burr
Aug 8, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ryan C Riddle, Henry J Donahue
Nov 15, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Bart Clarke
Feb 7, 2009·Tissue Engineering. Part B, Reviews·Benjamin D Elder, Kyriacos A Athanasiou
Jun 11, 2009·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Hanifeh KhayyeriPatrick J Prendergast
Oct 7, 2009·Mathematical Medicine and Biology : a Journal of the IMA·R D O'DeaH M Byrne
Oct 13, 2009·Journal of Biomechanics·Jan-Hung ChenCraig A Simmons
Feb 13, 2010·Bone·Chao LiuLidan You
May 13, 2010·Journal of Biomechanical Engineering·J M OsborneS L Waters
Sep 3, 2010·Plastic and Reconstructive Surgery·Victor W WongGeoffrey C Gurtner
Feb 1, 2011·International Journal of Biological Sciences·A BoccaccioA Desiate
Mar 31, 2011·Biotechnology and Bioengineering·Warren L GraysonGordana Vunjak-Novakovic
Apr 15, 2011·Injury·Josh E Schroeder, Rami Mosheiff
Apr 19, 2011·Tissue Engineering. Part B, Reviews·Juliane RauhMaik Stiehler
Apr 21, 2011·Transplantation·Giuseppe OrlandoShay Soker
May 31, 2011·Frontiers in Bioscience (Landmark Edition)·Jeffrey Paul Gorski
Jun 2, 2011·BMC Medicine·Rozalia DimitriouPeter V Giannoudis
May 29, 2012·Plastic and Reconstructive Surgery·Donald W Buck, Gregory A Dumanian
Aug 27, 2014·Archives of Biochemistry and Biophysics·Katiucia Batista Silva Paiva, José Mauro Granjeiro
Sep 24, 2014·Acta Biomaterialia·J R HenstockS I Anderson

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Citations

Aug 15, 2018·Mathematical Medicine and Biology : a Journal of the IMA·Andrew L KrauseSarah L Waters
Apr 14, 2021·Npj Regenerative Medicine·S L WatersA J El Haj

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